Universität zu Köln

Truse, Richard, Smyk, Michael, Schulz, Jan, Herminghaus, Anna, Weber, Andreas P. M., Mettler-Altmann, Tabea, Bauer, Inge, Picker, Olaf and Vollmer, Christian (2019). Regional hypothermia improves gastric microcirculatory oxygenation during hemorrhage in dogs. PLoS One, 14 (12). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

Full text not available from this repository.

Abstract

Mild systemic hypothermia increases gastric mucosal oxygenation (mu HbO(2)) during hemorrhagic shock in dogs. In the context of critical blood loss hypothermia might be fatal due to adverse side effects. Selective regional hypothermia might overcome these limitations. The aim of our study was to analyze the effects of regional gastric and oral mucosal hypothermia on mu HbO(2) and perfusion (mu flow). In a cross-over study six anesthetized dogs were subjected to local oral and gastric mucosal hypothermia (34 degrees C), or maintenance of local normothermia during normovolemia and hemorrhage (-20% blood volume). Macro- and microcirculatory variables were recorded continuously. During normovolemia, local hypothermia increased gastric microcirculatory flow (mu flow) without affecting oxygenation (mu HbO(2)) or oral microcirculation. During mild hemorrhagic shock gastric mu HbO(2) decreased from 72 +/- 2% to 38 +/- 3% in the normothermic group. This was attenuated by local hypothermia, where mu HbO(2) was reduced from 74 +/- 3% to 52 +/- 4%. Local perfusion, oral microcirculation and macrocirculatory variables were not affected. Selective local hypothermia improves gastric mu HbO(2) during hemorrhagic shock without relevant side effects. In contrast to systemic hypothermia, regional mucosal hypothermia did not affect perfusion and oxygen supply during hemorrhage. Thus, the increased mu HbO(2) during local hypothermia rather indicates reduced mucosal oxygen demand.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Truse, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Smyk, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulz, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Herminghaus, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, Andreas P. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mettler-Altmann, Tabea UNSPECIFIED UNSPECIFIED UNSPECIFIED Bauer, Inge UNSPECIFIED UNSPECIFIED UNSPECIFIED Picker, Olaf UNSPECIFIED UNSPECIFIED UNSPECIFIED Vollmer, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-124596
DOI:	10.1371/journal.pone.0226146
Journal or Publication Title:	PLoS One
Volume:	14
Number:	12
Date:	2019
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language THERAPEUTIC HYPOTHERMIA; MODERATE HYPOTHERMIA; MILD HYPOTHERMIA; TRAUMA PATIENTS; CARDIAC-ARREST; BLOOD-LOSS; ANESTHESIA; SHOCK; MECHANISMS; PREDICTOR Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12459