Universität zu Köln

Hahn, Oliver ORCID: 0000-0001-9015-4545, Drews, Lisa F., Tatsuta, Takashi, Gkioni, Lisonia, Hendrich, Oliver, Zhang, Qifeng, Langer, Thomas, Pletcher, Scott, Wakelam, Michael J. O., Beyer, Andreas ORCID: 0000-0002-3891-2123, Groenke, Sebastian and Partridge, Linda (2019). A nutritional memory effect counteracts the benefits of dietary restriction in old mice. Nat. Metab., 1 (11). S. 1059 - 1085. LONDON: NATURE PUBLISHING GROUP. ISSN 2522-5812

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Abstract

Dietary restriction (DR) during adulthood can greatly extend lifespan and improve metabolic health in diverse species. However, whether DR in mammals is still effective when applied for the first time at old age remains elusive. Here, we report results of a late-life DR-switch experiment using 800 mice. Female mice aged 24 months were switched from an ad libitum (AL) diet to DR or vice versa. Strikingly, the switch from DR to AL acutely increases mortality, whereas the switch from AL to DR causes only a weak and gradual increase in survival, suggesting the body has a memory of earlier nutrition. RNA sequencing in liver and brown and white adipose tissue (BAT and WAT, respectively) demonstrates a largely refractory transcriptional and metabolic response in fat tissue to DR after an AL diet, particularly in WAT, and a proinflammatory signature in aged preadipocytes, which is prevented by chronic DR feeding. Our results provide evidence for a 'nutritional memory' as a limiting factor for DR-induced longevity and metabolic remodelling of WAT in mammals.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hahn, Oliver UNSPECIFIED orcid.org/0000-0001-9015-4545 UNSPECIFIED Drews, Lisa F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tatsuta, Takashi UNSPECIFIED UNSPECIFIED UNSPECIFIED Gkioni, Lisonia UNSPECIFIED UNSPECIFIED UNSPECIFIED Hendrich, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhang, Qifeng UNSPECIFIED UNSPECIFIED UNSPECIFIED Langer, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Pletcher, Scott UNSPECIFIED UNSPECIFIED UNSPECIFIED Wakelam, Michael J. O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Beyer, Andreas UNSPECIFIED orcid.org/0000-0002-3891-2123 UNSPECIFIED Groenke, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Partridge, Linda UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-128898
DOI:	10.1038/s42255-019-0121-0
Journal or Publication Title:	Nat. Metab.
Volume:	1
Number:	11
Page Range:	S. 1059 - 1085
Date:	2019
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2522-5812
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language WHITE ADIPOSE-TISSUE; CALORIC RESTRICTION; BROWN; LONGEVITY; PHOSPHATIDYLCHOLINE; METABOLISM; CANCER; HEALTH; THERMOGENESIS; RETARDATION Multiple languages Endocrinology & Metabolism Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12889