Salmanton-Garcia, Jon ORCID: 0000-0002-6766-8297, Seidel, Danila, Koehler, Philipp ORCID: 0000-0002-7386-7495, Mellinghoff, Sibylle C., Herbrecht, Raoul, Klimko, Nikolai, Racil, Zdenek, Falces-Romero, Iker, Ingram, Paul, Benitez-Penuela, Miguel-Angel, Yesid Rodriguez, Jose, Desoubeaux, Guillaume, Barac, Aleksandra ORCID: 0000-0002-0132-2277, Garcia-Vidal, Carolina ORCID: 0000-0002-8915-0683, Hoenigl, Martin ORCID: 0000-0002-1653-2824, Mehta, Sanjay R., Cheng, Matthew P., Klyasova, Galina, Heinz, Werner J., Iqbal, Nousheen, Krause, Robert, Ostermann, Helmut, Penack, Olaf, Schalk, Enrico, Sheppard, Donald C., Willinger, Birgit, Wisplinghoff, Hilmar, Vehreschild, J. Janne, Cornely, Oliver A., Vehreschild, Maria J. G. T., Khedr, Reham AbdeLaziz, Arencibia-Nunez, Alberto, Aviles-Robles, Martha, Banke, Ingo, Basher, ArifuL, Benachinamardi, Keertilaxmi, Bertz, Harmut, Chakrabarti, Arunaloke, Drgona, Lubos, Garcia-Martinez, Jesus, Garcia-Rodriguez, Julio, Graber, Sandra, Harter, Georg ORCID: 0000-0001-9946-6246, Klein, Michael, Kouba, MichaL, Lee, Dong-Gun, Le Govic, Yohann, Leo, Fabian, Maertens, Johan, Maschmeyer, Georg, Meintker, Lisa, Mo, Xiao-Dong, Muller, Lena-Katharina, Muller, Nicolas, Nel, Jeremy Stephen, Novak, Jan, Patel, AtuL, Pfafflin, Frieder, Pozo-Laderas, Juan-Carlos, Puerta-Alcalde, Pedro, Rodriguez-Guardado, Azucena, Schroers, Roland, Shekar, Vandana, Shenoi, Susan, Silling, Gerda, Vinh, Donald, Waizel-Haiat, Salomon, Yee Yee, Mandy Yap, Prakash, Peralam Yegneswaran ORCID: 0000-0003-3117-0283 and Zak, Pavel (2019). Matched-paired analysis of patients treated for invasive mucormycosis: standard treatment versus posaconazole new formulations (MoveOn). J. Antimicrob. Chemother., 74 (11). S. 3315 - 3328. OXFORD: OXFORD UNIV PRESS. ISSN 1460-2091

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Abstract

Background: First-line antifungal treatment for invasive mucormycosis (IM) consists of liposomal amphotericin B. Salvage treatment options are limited and often based on posaconazole oral suspension. With the approval of posaconazole new formulations, patients could benefit from improved pharmacokinetics, safety and tolerability. Objectives: Our aim was to assess the effectiveness of posaconazole new formulations for IM treatment. Methods: We performed a case-matched analysis with proven or probable IM patients from the FungiScope (R) Registry. First-line posaconazole new formulations (1st-POSnew) and first-line amphotericin B plus posaconazole new formulations (1st-AMB+POSnew) cases were matched with first-line amphotericin B-based (1st-AMB) treatment controls. Salvage posaconazole new formulations (SAL-POSnew) cases were matched with salvage posaconazole oral suspension (SAL-POSsusp) controls. Each case was matched with up to three controls (based on severity, haematological/oncological malignancy, surgery and/or renal dysfunction). Results: Five patients receiving 1st-POSnew, 18 receiving 1st-AMB+POSnew and 22 receiving SAL-POSnew were identified. By day 42, a favourable response was reported for 80.0% (n=4/5) of patients receiving 1st-POSnew, for 27.8% (n=5/18) receiving 1st-AMB+POSnew and for 50.0% (n=11/22) receiving SAL-POSnew. Day 42 all-cause mortality of patients receiving posaconazole new formulations was lower compared with controls [20.0% (n=1/5) in 1st-POSnew versus 53.3% (n=8/15) in 1st-AMB; 33.3% (n=6/18) in 1st-AMB+POSnew versus 52.0% (n=26/50) in 1st-AMB; and 0.0% (n=0/22) in SAL-POSnew versus 4.4% (n=2/45) in SAL-POSsusp]. Conclusions: Posaconazole new formulations were effective in terms of treatment response and associated mortality of IM. While posaconazole new formulations may be an alternative for treatment of IM, the limited sample size of our study calls for a cautious interpretation of these observations.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Salmanton-Garcia, JonUNSPECIFIEDorcid.org/0000-0002-6766-8297UNSPECIFIED
Seidel, DanilaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koehler, PhilippUNSPECIFIEDorcid.org/0000-0002-7386-7495UNSPECIFIED
Mellinghoff, Sibylle C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herbrecht, RaoulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klimko, NikolaiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Racil, ZdenekUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Falces-Romero, IkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ingram, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Benitez-Penuela, Miguel-AngelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yesid Rodriguez, JoseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Desoubeaux, GuillaumeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barac, AleksandraUNSPECIFIEDorcid.org/0000-0002-0132-2277UNSPECIFIED
Garcia-Vidal, CarolinaUNSPECIFIEDorcid.org/0000-0002-8915-0683UNSPECIFIED
Hoenigl, MartinUNSPECIFIEDorcid.org/0000-0002-1653-2824UNSPECIFIED
Mehta, Sanjay R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cheng, Matthew P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klyasova, GalinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heinz, Werner J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Iqbal, NousheenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krause, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ostermann, HelmutUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Penack, OlafUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schalk, EnricoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sheppard, Donald C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Willinger, BirgitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wisplinghoff, HilmarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vehreschild, J. JanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cornely, Oliver A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vehreschild, Maria J. G. T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khedr, Reham AbdeLazizUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arencibia-Nunez, AlbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aviles-Robles, MarthaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Banke, IngoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Basher, ArifuLUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Benachinamardi, KeertilaxmiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bertz, HarmutUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chakrabarti, ArunalokeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drgona, LubosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia-Martinez, JesusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia-Rodriguez, JulioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Graber, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harter, GeorgUNSPECIFIEDorcid.org/0000-0001-9946-6246UNSPECIFIED
Klein, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kouba, MichaLUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, Dong-GunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Le Govic, YohannUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leo, FabianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maertens, JohanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maschmeyer, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meintker, LisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mo, Xiao-DongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muller, Lena-KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muller, NicolasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nel, Jeremy StephenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Novak, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Patel, AtuLUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfafflin, FriederUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pozo-Laderas, Juan-CarlosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Puerta-Alcalde, PedroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodriguez-Guardado, AzucenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schroers, RolandUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shekar, VandanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shenoi, SusanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Silling, GerdaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vinh, DonaldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Waizel-Haiat, SalomonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yee Yee, Mandy YapUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prakash, Peralam YegneswaranUNSPECIFIEDorcid.org/0000-0003-3117-0283UNSPECIFIED
Zak, PavelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-129115
DOI: 10.1093/jac/dkz344
Journal or Publication Title: J. Antimicrob. Chemother.
Volume: 74
Number: 11
Page Range: S. 3315 - 3328
Date: 2019
Publisher: OXFORD UNIV PRESS
Place of Publication: OXFORD
ISSN: 1460-2091
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
LIPOSOMAL AMPHOTERICIN-B; MYCOSES STUDY-GROUP; TRANSPLANT RECIPIENTS; EUROPEAN-ORGANIZATION; TABLET FORMULATION; FUNGAL-INFECTIONS; ORAL TABLET; PHARMACOKINETICS; THERAPY; SAFETYMultiple languages
Infectious Diseases; Microbiology; Pharmacology & PharmacyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/12911

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