Hensel, Lukas, Hoffstaedter, Felix, Caspers, Julian, Michely, Jochen, Mathys, Christian, Heller, Julia, Eickhoff, Claudia R., Reetz, Kathrin, Suedmeyer, Martin, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Schnitzler, Alfons ORCID: 0000-0002-6414-7939, Grefkes, Christian ORCID: 0000-0002-1656-720X and Eickhoff, Simon B. ORCID: 0000-0001-6363-2759 (2019). Functional Connectivity Changes of Key Regions for Motor Initiation in Parkinson's Disease. Cereb. Cortex, 29 (1). S. 383 - 397. CARY: OXFORD UNIV PRESS INC. ISSN 1460-2199

Full text not available from this repository.

Abstract

Akinesia, a cardinal symptom of Parkinson's disease, has been linked to abnormal activation in putamen and posterior medial frontal cortex (pMFC). However, little is known whether clinical severity of akinesia is linked to dysfunctional connectivity of these regions. Using a seed-based approach, we here investigated resting-state functional connectivity (RSFC) of putamen, pMFC and primary motor cortex (M1) in 60 patients with Parkinson's disease on regular medication and 72 healthy controls. We found that in patients putamen featured decreases of connectivity for a number of cortical and subcortical areas engaged in sensorimotor and cognitive processing. In contrast, the pMFC showed reduced connectivity with a more focal cortical network involved in higher-level motor-cognition. Finally, M1 featured a selective disruption of connectivity in a network specifically connected with M1. Correlating clinical impairment with connectivity changes revealed a relationship between akinesia and reduced RSFC between pMFC and left intraparietal lobule (IPL). Together, the present study demonstrated RSFC decreases in networks for motor initiation and execution in Parkinson's disease. Moreover, results suggest a relationship between pMFC-IPL decoupling and the manifestation of akinetic symptoms.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Hensel, LukasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoffstaedter, FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caspers, JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Michely, JochenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mathys, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heller, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eickhoff, Claudia R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reetz, KathrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Suedmeyer, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fink, Gereon R.UNSPECIFIEDorcid.org/0000-0002-8230-1856UNSPECIFIED
Schnitzler, AlfonsUNSPECIFIEDorcid.org/0000-0002-6414-7939UNSPECIFIED
Grefkes, ChristianUNSPECIFIEDorcid.org/0000-0002-1656-720XUNSPECIFIED
Eickhoff, Simon B.UNSPECIFIEDorcid.org/0000-0001-6363-2759UNSPECIFIED
URN: urn:nbn:de:hbz:38-139627
DOI: 10.1093/cercor/bhy259
Journal or Publication Title: Cereb. Cortex
Volume: 29
Number: 1
Page Range: S. 383 - 397
Date: 2019
Publisher: OXFORD UNIV PRESS INC
Place of Publication: CARY
ISSN: 1460-2199
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
EXTERNALLY TRIGGERED MOVEMENTS; ANTERIOR CINGULATE CORTEX; CEREBRAL-BLOOD-FLOW; BASAL GANGLIA; SUBTHALAMIC NUCLEUS; PARIETAL CORTEX; FRONTAL-LOBE; SENSORIMOTOR INTEGRATION; EXECUTIVE DYSFUNCTION; DOPAMINE DYSFUNCTIONMultiple languages
NeurosciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/13962

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item