Universität zu Köln

Barbe, Anna Greta, Ludwar, Lena, Hamacher, Stefanie ORCID: 0000-0003-2158-9101 and Noack, Michael Johannes (2019). Efficacy of a newly developed mouth gel for xerostomia relief-A randomized double-blind trial. Oral Dis., 25 (6). S. 1519 - 1530. HOBOKEN: WILEY. ISSN 1601-0825

Full text not available from this repository.

Abstract

Objectives To determine the efficacy of a new symptom-relieving mouth gel vs. a widely used control gel on xerostomic burden. Materials and methods This randomized, double-blind, crossover trial investigated the efficacy of the test gel (Dr. Wolff Gel) vs. control (Biotene) in participants with xerostomia (n = 32; mean age 60 years). Oral examinations were taken at baseline, and xerostomic visual analogue scales (xVAS), after-use questionnaires and willingness to pay were investigated before and after use. Results Neither gel reduced xerostomic burden (xVAS) after 7-day application. There was some preference for the test gel regarding taste and healthy gum feeling. After 1-time application, there were differences favouring the test gel for symptom-relieving effects between test gel and water (p < 0.001), mucosal adhesion (p < 0.001) and taste persistence (p < 0.001). Overall symptomatic relief with the test gel lasted around 2 hr. Conclusions No mouth gel alleviated the overall xerostomic burden. Nevertheless, the test gel led to short-term perceived symptomatic relief and improved patient-centred outcomes as taste and perceived gum health. The gel will probably mainly be effective at moments that patients mostly suffer from xerostomia. Selection of a product will be based on perceived subjective differences and their value in the context of the overall xerostomic burden.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Barbe, Anna Greta UNSPECIFIED UNSPECIFIED UNSPECIFIED Ludwar, Lena UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamacher, Stefanie UNSPECIFIED orcid.org/0000-0003-2158-9101 UNSPECIFIED Noack, Michael Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-142419
DOI:	10.1111/odi.13105
Journal or Publication Title:	Oral Dis.
Volume:	25
Number:	6
Page Range:	S. 1519 - 1530
Date:	2019
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1601-0825
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SALIVARY-GLAND DYSFUNCTION; ORAL MEDICINE VI; WORLD WORKSHOP; DRY MOUTH; WHOLE SALIVA; SYMPTOMS; HEALTH; DISEASE; LACTOPEROXIDASE; HYPOSALIVATION Multiple languages Dentistry, Oral Surgery & Medicine Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14241