Universität zu Köln

Graf, Robin ORCID: 0000-0002-5400-9938, Seagal, Jane, Section, Kevin L. Otipoby, Lam, Kong-Peng ORCID: 0000-0002-1316-4333, Ayoub, Salah, Zhang, Baochun ORCID: 0000-0003-1759-1161, Sander, Sandrine and Rajewsky, Klaus ORCID: 0000-0002-6633-6370 (2019). BCR-dependent lineage plasticity in mature B cells. Science, 363 (6428). S. 748 - 778. WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE. ISSN 1095-9203

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Abstract

B2 cells engage in classical antibody responses, whereas B1 cells are considered carriers of innate immunity, biased toward recognizing epitopes present on the surfaces of common pathogens and self antigens. To explore the role of B cell antigen receptor (BCR) specificity in driving B1 cell differentiation, we developed a transgenic system allowing us to change BCR specificity in B cells in an inducible and programmedmanner. Mature B2 cells differentiated into bona fide B1 cells upon acquisition of a B1 cell-typical self-reactive BCR through a phase of proliferative expansion. Thus, B2 cells have B1 cell differentiation potential in addition to their classical capacity to differentiate into memory and plasma cells, and B1 differentiation can be instructed by BCR-mediated self-reactivity, in the absence of B1-lineage precommitment.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Graf, Robin UNSPECIFIED orcid.org/0000-0002-5400-9938 UNSPECIFIED Seagal, Jane UNSPECIFIED UNSPECIFIED UNSPECIFIED Section, Kevin L. Otipoby UNSPECIFIED UNSPECIFIED UNSPECIFIED Lam, Kong-Peng UNSPECIFIED orcid.org/0000-0002-1316-4333 UNSPECIFIED Ayoub, Salah UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhang, Baochun UNSPECIFIED orcid.org/0000-0003-1759-1161 UNSPECIFIED Sander, Sandrine UNSPECIFIED UNSPECIFIED UNSPECIFIED Rajewsky, Klaus UNSPECIFIED orcid.org/0000-0002-6633-6370 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-156576
DOI:	10.1126/science.aau8475
Journal or Publication Title:	Science
Volume:	363
Number:	6428
Page Range:	S. 748 - 778
Date:	2019
Publisher:	AMER ASSOC ADVANCEMENT SCIENCE
Place of Publication:	WASHINGTON
ISSN:	1095-9203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANTIGEN RECEPTOR SPECIFICITY; LY-1 B; PHOSPHATIDYL CHOLINE; MARGINAL ZONE; B-1 CELLS; VH GENE; GENERATION; REARRANGEMENT; REPERTOIRE; EXPRESSION Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15657