Teipel, Stefan J., Kuper-Smith, Jan O., Bartels, Claudia, Brosseron, Frederic, Buchmann, Martina, Buerger, Katharina, Catak, Cihan, Janowitz, Daniel, Dechent, Peter, Dobisch, Laura, Ertl-Wagnerm, Birgit, Fliessbach, Klaus, Haynes, John-Dylan, Heneka, Michael T., Kilimann, Ingo, Laske, Christoph, Li, Siyao, Menne, Felix, Metzger, Coraline D., Priller, Josef, Pross, Verena, Ramirez, Alfredo ORCID: 0000-0003-4991-763X, Scheffler, Klaus ORCID: 0000-0001-6316-8773, Schneider, Anja ORCID: 0000-0001-9540-8700, Spottke, Annika, Spruth, Eike J., Wagner, Michael ORCID: 0000-0003-2589-6440, Wiltfang, Jens ORCID: 0000-0003-1492-5330, Wolfsgruber, Steffen, Duezel, Emrah, Jessen, Frank and Dyrba, Martin (2019). Multicenter Tract-Based Analysis of Microstructural Lesions within the Alzheimer's Disease Spectrum: Association with Amyloid Pathology and Diagnostic Usefulness. J. Alzheimers Dis., 72 (2). S. 455 - 466. AMSTERDAM: IOS PRESS. ISSN 1875-8908

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Abstract

Diffusion changes as determined by diffusion tensor imaging are potential indicators of microstructural lesions in people with mild cognitive impairment (MCI), prodromal Alzheimer's disease (AD), and AD dementia. Here we extended the scope of analysis toward subjective cognitive complaints as a pre-MCI at risk stage of AD. In a cohort of 271 participants of the prospective DELCODE study, including 93 healthy controls and 98 subjective cognitive decline (SCD), 45 MCI, and 35 AD dementia cases, we found reductions of fiber tract integrity in limbic and association fiber tracts in MCI and AD dementia compared with controls in a tract-based analysis (p < 0.05, family wise error corrected). In contrast, people with SCD showed spatially restricted white matter alterations only for the mode of anisotropy and only at an uncorrected level of significance. DTI parameters yielded a high cross-validated diagnostic accuracy of almost 80% for the clinical diagnosis of MCI and the discrimination of A beta positive MCI cases from A beta negative controls. In contrast, DTI parameters reached only random level accuracy for the discrimination between A beta positive SCD and control cases from A beta negative controls. These findings suggest that in prodromal stages of AD, such as in A beta positive MCI, multicenter DTI with prospectively harmonized acquisition parameters yields diagnostic accuracy meeting the criteria for a useful biomarker. In contrast, automated tractbased analysis of DTI parameters is not useful for the identification of preclinical AD, including A beta positive SCD and control cases.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Teipel, Stefan J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuper-Smith, Jan O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bartels, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brosseron, FredericUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buchmann, MartinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buerger, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Catak, CihanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Janowitz, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dechent, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dobisch, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ertl-Wagnerm, BirgitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fliessbach, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haynes, John-DylanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heneka, Michael T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kilimann, IngoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laske, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Li, SiyaoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Menne, FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Metzger, Coraline D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Priller, JosefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pross, VerenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ramirez, AlfredoUNSPECIFIEDorcid.org/0000-0003-4991-763XUNSPECIFIED
Scheffler, KlausUNSPECIFIEDorcid.org/0000-0001-6316-8773UNSPECIFIED
Schneider, AnjaUNSPECIFIEDorcid.org/0000-0001-9540-8700UNSPECIFIED
Spottke, AnnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spruth, Eike J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, MichaelUNSPECIFIEDorcid.org/0000-0003-2589-6440UNSPECIFIED
Wiltfang, JensUNSPECIFIEDorcid.org/0000-0003-1492-5330UNSPECIFIED
Wolfsgruber, SteffenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duezel, EmrahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dyrba, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-160366
DOI: 10.3233/JAD-190446
Journal or Publication Title: J. Alzheimers Dis.
Volume: 72
Number: 2
Page Range: S. 455 - 466
Date: 2019
Publisher: IOS PRESS
Place of Publication: AMSTERDAM
ISSN: 1875-8908
Language: English
Faculty: Faculty of Management, Economy and Social Sciences
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MILD COGNITIVE IMPAIRMENT; WHITE-MATTER INTEGRITY; DIFFUSION-TENSOR; HARMONIZED PROTOCOL; NATIONAL INSTITUTE; GRAY-MATTER; MRI; DTI; DEMENTIA; DECLINEMultiple languages
NeurosciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/16036

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