Rohde, Anna M., Zweigner, Janine, Wiese-Posselt, Miriam, Schwab, Frank, Behnke, Michael, Kola, Axel, Obermann, Birgit, Knobloch, Johannes K. -M., Feihl, Susanne, Querbach, Christiane, Gebhardt, Friedemann, Mischnik, Alexander, Ihle, Vera, Schroeder, Wiebke, Armean, Sabina, Peter, Silke, Tacconelli, Evelina, Hamprecht, Axel ORCID: 0000-0003-1449-5780, Seifert, Harald, Vehreschild, Maria J. G. T., Kern, Winfried V., Gastmeier, Petra ORCID: 0000-0001-5520-4287, Buhl, Michael, Busch, Dirk, Eisenbeis, Simone, Foerst, Gesche, Foschi, Federico, Gillis, Meyke, Hansen, Dorothea, Haecker, Georg, Heim, Markus, Hug, Martin, Kaier, Klaus ORCID: 0000-0003-0837-6945, Kuepper, Fabian, Langebartels, Georg, Liekweg, Andrea, Lipp, Hans-Peter, Maertin, Nayana, Nordmann, Mathias, Pelzer, Andrea, Pena-Diaz, Luis-Alberto, Rupp, Jan, Schroeder, Christin, Spohn, Katrin, Steib-Bauert, Michaela, Vehreschild, Joerg J., vor dem Esche, Ulrich and Wolke, Solvy (2018). Incidence of infections due to third generation cephalosporin-resistant Enterobacteriaceae - a prospective multicentre cohort study in six German university hospitals. Antimicrob. Resist. Infect. Control, 7. LONDON: BMC. ISSN 2047-2994

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Abstract

BackgroundInfections caused by third generation cephalosporin-resistant Enterobacteriaceae (3GCREB) are an increasing healthcare problem. We aim to describe the 3GCREB infection incidence and compare it to prevalence upon admission. In addition, we aim to describe infections caused by 3GCREB, which are also carbapenem resistant (CRE).MethodsIn 2014-2015, we performed prospective 3GCREB surveillance in clinically relevant patient specimens (screening specimens excluded). Infections counted as hospital-acquired (HAI) when the 3GCREB was detected after the third day following admission, otherwise as community-acquired infection (CAI).ResultsOf 578,420 hospitalized patients under surveillance, 3367 had a 3GCREB infection (0.58%). We observed a similar 3GCREB CAI and HAI incidence (0.28 and 0.31 per 100 patients, respectively). The most frequent pathogen was 3GCR E. coli, in CAI and HAI (0.15 and 0.12 per 100 patients). We observed a CRE CAI incidence of 0.006 and a HAI incidence of 0.008 per 100 patients (0.014 per 1000 patient days).ConclusionsComparing the known 3GCREB admission prevalence of the participating hospitals (9.5%) with the percentage of patients with a 3GCREB infection (0.58%), we conclude the prevalence of 3GCREB in university hospitals to be about 16 times higher than suggested when only patients with 3GCREB infections are considered. Moreover, we find the HAI and CAI incidence caused by CRE in Germany to be relatively low.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Rohde, Anna M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zweigner, JanineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiese-Posselt, MiriamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schwab, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Behnke, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kola, AxelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Obermann, BirgitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knobloch, Johannes K. -M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Feihl, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Querbach, ChristianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gebhardt, FriedemannUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mischnik, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ihle, VeraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schroeder, WiebkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Armean, SabinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peter, SilkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tacconelli, EvelinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hamprecht, AxelUNSPECIFIEDorcid.org/0000-0003-1449-5780UNSPECIFIED
Seifert, HaraldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vehreschild, Maria J. G. T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kern, Winfried V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gastmeier, PetraUNSPECIFIEDorcid.org/0000-0001-5520-4287UNSPECIFIED
Buhl, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Busch, DirkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eisenbeis, SimoneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Foerst, GescheUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Foschi, FedericoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gillis, MeykeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hansen, DorotheaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haecker, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heim, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hug, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaier, KlausUNSPECIFIEDorcid.org/0000-0003-0837-6945UNSPECIFIED
Kuepper, FabianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Langebartels, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liekweg, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lipp, Hans-PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maertin, NayanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nordmann, MathiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pelzer, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pena-Diaz, Luis-AlbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rupp, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schroeder, ChristinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spohn, KatrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steib-Bauert, MichaelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vehreschild, Joerg J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
vor dem Esche, UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolke, SolvyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-161713
DOI: 10.1186/s13756-018-0452-8
Journal or Publication Title: Antimicrob. Resist. Infect. Control
Volume: 7
Date: 2018
Publisher: BMC
Place of Publication: LONDON
ISSN: 2047-2994
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CARBAPENEMASE-PRODUCING ENTEROBACTERIACEAE; PREVALENCE; EUSCAPE; CAREMultiple languages
Public, Environmental & Occupational Health; Infectious Diseases; Microbiology; Pharmacology & PharmacyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/16171

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