Lerch, Christian, Shroff, Rukshana, Wan, Mandy ORCID: 0000-0001-8802-0425, Rees, Lesley, Aitkenhead, Helen, Bulut, Ipek Kaplan, Thurn, Daniela, Bayazit, Aysun Karabay, Niemirska, Anna, Canpolat, Nur ORCID: 0000-0002-3420-9756, Duzova, Ali, Azukaitis, Karolis, Yilmaz, Ebru, Yalcinkaya, Fatos, Harambat, Jerome ORCID: 0000-0003-2016-120X, Kiyak, Aysel, Alpay, Harika, Habbig, Sandra, Zaloszyc, Ariane, Soylemezoglu, Oguz, Candan, Cengiz, Rosales, Alejandra, Melk, Anette, Querfeld, Uwe, Leifheit-Nestler, Maren ORCID: 0000-0002-9203-7622, Sander, Anja, Schaefer, Franz, Haffner, Dieter, Cortina, G., Arbeiter, K., Dusek, J., Harambat, J., Ranchin, B., Fischbach, M., Zalosczyk, A., Querfeld, U., Habbig, S., Galiano, M., Buescher, R., Gimpel, C., Kemper, M., Melk, A., Thurn, D., Schaefer, F., Doyon, A., Wuehl, E., Pohl, M., Wygoda, S., Jeck, N., Kranz, B., Wigger, M., Montini, G., Lugani, F., Testa, S., Vidal, E., Matteucci, C., Picca, S., Jankauskiene, A., Azukaitis, K., Zurowska, A., Drodz, D., Tkaczyk, M., Urasinski, T., Litwin, M., Niemirska, A., Szczepanska, M., Texeira, A., Peco-Antic, A., Bucher, B., Laube, G., Anarat, A., Bayazit, A. K., Yalcinkaya, F., Basin, E., Cakar, N., Soylemezoglu, O., Duzova, A., Bilginer, Y., Erdogan, H., Donmez, O., Balat, A., Kiyak, A., Caliskan, S., Canpolat, N., Candan, C., Civilibal, M., Emre, S., Alpay, H., Ozcelik, G., Mir, S., Sozeri, B., Yavascan, O., Tabel, Y., Ertan, P., Yilmaz, E., Shroff, R., Prytula, A., Bachetta, J., Haffner, D., Klaus, G., Gessner, M., Schmitt, C. P., Stabouli, S., Reusz, G., Verrina, E., Groothoff, J., Tondel, C., Gamero, M. A., Petrosyan, E., Bakkaloglu, S. A., Dursun, I. and Shroff, R. (2018). Effects of nutritional vitamin D supplementation on markers of bone and mineral metabolism in children with chronic kidney disease. Nephrol. Dial. Transplant., 33 (12). S. 2208 - 2218. OXFORD: OXFORD UNIV PRESS. ISSN 1460-2385

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Abstract

Background. We investigated the effects of nutritional vitamin D supplementation on markers of bone and mineral metabolism, i.e. serum levels of fibroblast growth factor 23 (FGF23), Klotho, bone alkaline phosphatase (BAP) and sclerostin, in two cohorts with chronic kidney disease (CKD). Methods. In all, 80 vitamin D-deficient children were selected: 40 with mild to moderate CKD from the ERGO study, a randomized trial of ergocalciferol supplementation [ estimated glomerular filtration rate (eGFR) 55 mL/min/1.73 m(2)], and 40 with advanced CKD from the observational Cardiovascular Comorbidity in Children with Chronic Kidney Disease (4C) study (eGFR 24 mL/min/1.73 m2). In each study, vitamin D supplementation was started in 20 children and 20 matched children not receiving vitamin D served as controls. Measures were taken at baseline and after a median period of 8 months. Age- and gender-related standard deviation scores (SDSs) were calculated. Results. Before vitamin D supplementation, children in the ERGO study had normal FGF23 (median 0.31 SDS) and BAP (-0.10 SDS) but decreased Klotho and sclerostin (-0.77 and -1.04 SDS, respectively), whereas 4C patients had increased FGF23 (3.87 SDS), BAP (0.78 SDS) and sclerostin (0.76 SDS) but normal Klotho (-0.27 SDS) levels. Vitamin D supplementation further increased FGF23 in 4C but not in ERGO patients. Serum Klotho and sclerostin normalized with vitamin D supplementation in ERGO but remained unchanged in 4C patients. BAP levels were unchanged in all patients. In the total cohort, significant effects of vitamin D supplementation were noted for Klotho at eGFR 40-70 mL/min/1.73 m(2). Conclusions. Vitamin D supplementation normalized Klotho and sclerostin in children with mild to moderate CKD but further increased FGF23 in advanced CKD.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Lerch, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shroff, RukshanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wan, MandyUNSPECIFIEDorcid.org/0000-0001-8802-0425UNSPECIFIED
Rees, LesleyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aitkenhead, HelenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bulut, Ipek KaplanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thurn, DanielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bayazit, Aysun KarabayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Niemirska, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Canpolat, NurUNSPECIFIEDorcid.org/0000-0002-3420-9756UNSPECIFIED
Duzova, AliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Azukaitis, KarolisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yilmaz, EbruUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yalcinkaya, FatosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harambat, JeromeUNSPECIFIEDorcid.org/0000-0003-2016-120XUNSPECIFIED
Kiyak, AyselUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alpay, HarikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Habbig, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zaloszyc, ArianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soylemezoglu, OguzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Candan, CengizUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosales, AlejandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Melk, AnetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Querfeld, UweUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leifheit-Nestler, MarenUNSPECIFIEDorcid.org/0000-0002-9203-7622UNSPECIFIED
Sander, AnjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaefer, FranzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haffner, DieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cortina, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arbeiter, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dusek, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harambat, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ranchin, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fischbach, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zalosczyk, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Querfeld, U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Habbig, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Galiano, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buescher, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gimpel, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kemper, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Melk, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thurn, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaefer, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Doyon, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wuehl, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pohl, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wygoda, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jeck, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kranz, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wigger, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Montini, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lugani, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Testa, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vidal, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Matteucci, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Picca, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jankauskiene, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Azukaitis, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zurowska, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drodz, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tkaczyk, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Urasinski, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Litwin, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Niemirska, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Szczepanska, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Texeira, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peco-Antic, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bucher, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laube, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anarat, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bayazit, A. K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yalcinkaya, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Basin, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cakar, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soylemezoglu, O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duzova, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bilginer, Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Erdogan, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Donmez, O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Balat, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kiyak, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caliskan, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Canpolat, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Candan, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Civilibal, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Emre, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alpay, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ozcelik, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mir, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sozeri, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yavascan, O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tabel, Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ertan, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yilmaz, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shroff, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prytula, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bachetta, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haffner, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klaus, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gessner, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmitt, C. P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stabouli, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reusz, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Verrina, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Groothoff, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tondel, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gamero, M. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Petrosyan, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bakkaloglu, S. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dursun, I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shroff, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-162903
DOI: 10.1093/ndt/gfy012
Journal or Publication Title: Nephrol. Dial. Transplant.
Volume: 33
Number: 12
Page Range: S. 2208 - 2218
Date: 2018
Publisher: OXFORD UNIV PRESS
Place of Publication: OXFORD
ISSN: 1460-2385
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GROWTH-FACTOR 23; SERUM SCLEROSTIN; CHOLECALCIFEROL SUPPLEMENTATION; HEMODIALYSIS-PATIENTS; RENAL-FAILURE; ALPHA-KLOTHO; DOUBLE-BLIND; FGF-23; CKD; ERGOCALCIFEROLMultiple languages
Transplantation; Urology & NephrologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/16290

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