Park, Se Eun, Boinett, Christine, Wong, Vanessa K., Pak, Gi Deok, Panzner, Ursula, Espinoza, Ligia Maria Cruz, von Kalckreuth, Vera, Im, Justin, Schuett-Gerowitt, Heidi, Crump, John A. ORCID: 0000-0002-4529-102X, Breiman, Robert F., Adu-Sarkodie, Yaw, Owusu-Dabo, Ellis, Rakotozandrindrainy, Raphael, Soura, Abdramane Bassiahi, Aseffa, Abraham ORCID: 0000-0002-8028-1150, Gasmelseed, Nagla, Keddy, Karen H., May, Juergen, Sow, Amy Gassama, Aaby, Peter, Biggs, Holly M., Hertz, Julian T., Montgomery, Joel M., Cosmas, Leonard, Olack, Beatrice, Fields, Barry, Sarpong, Nimako, Razafindrabe, Tsiriniaina Jean Luco, Raminosoa, Tiana Mirana, Kabore, Leon Parfait, Sampo, Emmanuel, Teferi, Mekonnen, Yeshitela, Biruk, El Tayeb, Muna Ahmed, Sooka, Arvinda, Meyer, Christian G., Krumkamp, Ralf, Dekker, Denise Myriam, Jaeger, Anna, Poppert, Sven, Tall, Adama, Niang, Aissatou, Bjerregaard-Andersen, Morten, Lofberg, Sandra Valborg, Seo, Hye Jin, Jeon, Hyon Jin, Deerin, Jessica Fung, Park, Jinkyung, Konings, Frank, Ali, Mohammad, Clemens, John D., Hughes, Peter, Sendagala, Juliet Nsimire, Vudriko, Tobias, Downing, Robert, Ikumapayi, Usman N., Mackenzie, Grant A., Obaro, Stephen, Argimon, Silvia, Aanensen, David M., Page, Andrew, Keane, Jacqueline A. ORCID: 0000-0003-0739-6848, Duchene, Sebastian ORCID: 0000-0002-2863-0907, Dyson, Zoe, Holt, Kathryn E., Dougan, Gordon, Marks, Florian ORCID: 0000-0002-6043-7170 and Baker, Stephen (2018). The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa. Nat. Commun., 9. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

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Abstract

There is paucity of data regarding the geographical distribution, incidence, and phylogenetics of multi-drug resistant (MDR) Salmonella Typhi in sub-Saharan Africa. Here we present a phylogenetic reconstruction of whole genome sequenced 249 contemporaneous S. Typhi isolated between 2008-2015 in 11 sub-Saharan African countries, in context of the 2,057 global S. Typhi genomic framework. Despite the broad genetic diversity, the majority of organisms (225/249; 90%) belong to only three genotypes, 4.3.1 (H58) (99/249; 40%), 3.1.1 (97/249; 39%), and 2.3.2 (29/249; 12%). Genotypes 4.3.1 and 3.1.1 are confined within East and West Africa, respectively. MDR phenotype is found in over 50% of organisms restricted within these dominant genotypes. High incidences of MDR S. Typhi are calculated in locations with a high burden of typhoid, specifically in children aged <15 years. Antimicrobial stewardship, MDR surveillance, and the introduction of typhoid conjugate vaccines will be critical for the control of MDR typhoid in Africa.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Park, Se EunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boinett, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wong, Vanessa K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pak, Gi DeokUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Panzner, UrsulaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Espinoza, Ligia Maria CruzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Kalckreuth, VeraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Im, JustinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schuett-Gerowitt, HeidiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Crump, John A.UNSPECIFIEDorcid.org/0000-0002-4529-102XUNSPECIFIED
Breiman, Robert F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adu-Sarkodie, YawUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Owusu-Dabo, EllisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rakotozandrindrainy, RaphaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soura, Abdramane BassiahiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aseffa, AbrahamUNSPECIFIEDorcid.org/0000-0002-8028-1150UNSPECIFIED
Gasmelseed, NaglaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Keddy, Karen H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
May, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sow, Amy GassamaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aaby, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Biggs, Holly M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hertz, Julian T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Montgomery, Joel M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cosmas, LeonardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Olack, BeatriceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fields, BarryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sarpong, NimakoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Razafindrabe, Tsiriniaina Jean LucoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Raminosoa, Tiana MiranaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kabore, Leon ParfaitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sampo, EmmanuelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teferi, MekonnenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yeshitela, BirukUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
El Tayeb, Muna AhmedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sooka, ArvindaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meyer, Christian G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krumkamp, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dekker, Denise MyriamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaeger, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Poppert, SvenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tall, AdamaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Niang, AissatouUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bjerregaard-Andersen, MortenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lofberg, Sandra ValborgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seo, Hye JinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jeon, Hyon JinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deerin, Jessica FungUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Park, JinkyungUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Konings, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ali, MohammadUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Clemens, John D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hughes, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sendagala, Juliet NsimireUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vudriko, TobiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Downing, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ikumapayi, Usman N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mackenzie, Grant A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Obaro, StephenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Argimon, SilviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aanensen, David M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Page, AndrewUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Keane, Jacqueline A.UNSPECIFIEDorcid.org/0000-0003-0739-6848UNSPECIFIED
Duchene, SebastianUNSPECIFIEDorcid.org/0000-0002-2863-0907UNSPECIFIED
Dyson, ZoeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holt, Kathryn E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dougan, GordonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marks, FlorianUNSPECIFIEDorcid.org/0000-0002-6043-7170UNSPECIFIED
Baker, StephenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-164936
DOI: 10.1038/s41467-018-07370-z
Journal or Publication Title: Nat. Commun.
Volume: 9
Date: 2018
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 2041-1723
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ENTERICA SEROVAR TYPHI; SURVEILLANCE; PLASMIDS; TOOLMultiple languages
Multidisciplinary SciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/16493

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