Garcia-Reyes, Balbina, Kretz, Anna-Laura, Ruff, Jan-Philipp, von Karstedt, Silvia, Hillenbrand, Andreas, Knippschild, Uwe, Henne-Bruns, Doris and Lemke, Johannes ORCID: 0000-0003-2142-6097 (2018). The Emerging Role of Cyclin-Dependent Kinases (CDKs) in Pancreatic Ductal Adenocarcinoma. Int. J. Mol. Sci., 19 (10). BASEL: MDPI. ISSN 1422-0067

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Abstract

The family of cyclin-dependent kinases (CDKs) has critical functions in cell cycle regulation and controlling of transcriptional elongation. Moreover, dysregulated CDKs have been linked to cancer initiation and progression. Pharmacological CDK inhibition has recently emerged as a novel and promising approach in cancer therapy. This idea is of particular interest to combat pancreatic ductal adenocarcinoma (PDAC), a cancer entity with a dismal prognosis which is owed mainly to PDAC's resistance to conventional therapies. Here, we review the current knowledge of CDK biology, its role in cancer and the therapeutic potential to target CDKs as a novel treatment strategy for PDAC.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Garcia-Reyes, BalbinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kretz, Anna-LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruff, Jan-PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Karstedt, SilviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hillenbrand, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knippschild, UweUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henne-Bruns, DorisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lemke, JohannesUNSPECIFIEDorcid.org/0000-0003-2142-6097UNSPECIFIED
URN: urn:nbn:de:hbz:38-170763
DOI: 10.3390/ijms19103219
Journal or Publication Title: Int. J. Mol. Sci.
Volume: 19
Number: 10
Date: 2018
Publisher: MDPI
Place of Publication: BASEL
ISSN: 1422-0067
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
INHIBITOR DINACICLIB MK-7965; CHRONIC LYMPHOCYTIC-LEUKEMIA; TRAIL-INDUCED APOPTOSIS; I DOSE-ESCALATION; CELL-CYCLE; PROTEIN-KINASE; S-PHASE; DNA-DAMAGE; REPLICATION STRESS; ANTITUMOR-ACTIVITYMultiple languages
Biochemistry & Molecular Biology; Chemistry, MultidisciplinaryMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/17076

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