Universität zu Köln

Fridman, Eran, Na'ara, Shorook, Agarwal, Jaiprakash, Amit, Moran, Bachar, Gideon, Villaret, Andrea Bolzoni, Brandao, Jose, Cernea, Claudio R., Chaturvedi, Pankaj, Clark, Jonathan, Ebrahimi, Ardalan, Fliss, Dan M., Jonnalagadda, Sashikanth, Kohler, Hugo F., Kowalski, Luiz P., Kreppel, Matthias, Liao, Chun-Ta, Patel, Snehal G., Patel, Rajan S., Robbins, K. Thomas, Shah, Jatin P., Shpitzer, Thomas, Yen, Tzu-Chen, Zoeller, Joachim E. and Gil, Ziv (2018). The Role of Adjuvant Treatment in Early-Stage Oral Cavity Squamous Cell Carcinoma: An International Collaborative Study. Cancer, 124 (14). S. 2948 - 2956. HOBOKEN: WILEY. ISSN 1097-0142

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Abstract

BACKGROUND: Up to half of patients with oral cavity squamous cell carcinoma (OCSCC) have stage I to II disease. When adequate resection is attained, no further treatment is needed; however, re-resection or radiotherapy may be indicated for patients with positive or close margins. This multicenter study evaluated the outcomes and role of adjuvant treatment in patients with stage I to II OCSCC.METHODS: Overall survival (OS), disease-specific survival, local-free survival, and disease-free survival rates were calculated with Kaplan-Meier analysis.RESULTS: Of 1257 patients with T1-2N0M0 disease, 33 (2.6%) had positive margins, and 205 (16.3%) had close margins. The 5-year OS rate was 80% for patients with clear margins, 52% for patients with close margins, and 63% for patients with positive margins (P<.0001). In a multivariate analysis, age, depth of invasion, and margins were independent predictors of outcome. Close margins were associated with a >2-fold increase in the risk of recurrence (P<.0001). The multivariate analysis revealed that adjuvant treatment significantly improved the outcomes of patients with close/positive margins (P=.002 to .03).CONCLUSIONS: Patients with stage I to II OCSCC and positive/close margins have poor long-term outcomes. For this population, adjuvant treatment may be associated with improved survival. (C) 2018 American Cancer Society.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fridman, Eran UNSPECIFIED UNSPECIFIED UNSPECIFIED Na'ara, Shorook UNSPECIFIED UNSPECIFIED UNSPECIFIED Agarwal, Jaiprakash UNSPECIFIED UNSPECIFIED UNSPECIFIED Amit, Moran UNSPECIFIED UNSPECIFIED UNSPECIFIED Bachar, Gideon UNSPECIFIED UNSPECIFIED UNSPECIFIED Villaret, Andrea Bolzoni UNSPECIFIED UNSPECIFIED UNSPECIFIED Brandao, Jose UNSPECIFIED UNSPECIFIED UNSPECIFIED Cernea, Claudio R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chaturvedi, Pankaj UNSPECIFIED UNSPECIFIED UNSPECIFIED Clark, Jonathan UNSPECIFIED UNSPECIFIED UNSPECIFIED Ebrahimi, Ardalan UNSPECIFIED UNSPECIFIED UNSPECIFIED Fliss, Dan M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jonnalagadda, Sashikanth UNSPECIFIED UNSPECIFIED UNSPECIFIED Kohler, Hugo F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kowalski, Luiz P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreppel, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Liao, Chun-Ta UNSPECIFIED UNSPECIFIED UNSPECIFIED Patel, Snehal G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Patel, Rajan S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Robbins, K. Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Shah, Jatin P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shpitzer, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Yen, Tzu-Chen UNSPECIFIED UNSPECIFIED UNSPECIFIED Zoeller, Joachim E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gil, Ziv UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-179705
DOI:	10.1002/cncr.31531
Journal or Publication Title:	Cancer
Volume:	124
Number:	14
Page Range:	S. 2948 - 2956
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1097-0142
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LOCALLY ADVANCED HEAD; LYMPH-NODE DENSITY; SURGICAL MARGINS; NECK CANCERS; CLOSE MARGIN; RECURRENCE; CHEMOTHERAPY; SURVIVAL; SURGERY; RADIOTHERAPY Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17970