Ravelli, Angelo, Consolaro, Alessandro ORCID: 0000-0002-0065-7614, Horneff, Gerd, Laxer, Ronald M., Lovell, Daniel J., Wulffraat, Nico M., Akikusa, Jonathan D., Al-Mayouf, Sulaiman M., Anton, Jordi ORCID: 0000-0002-8792-4219, Avcin, Tadej, Berard, Roberta A., Beresford, Michael W., Burgos-Vargas, Ruben ORCID: 0000-0003-1058-8955, Cimaz, Rolando, De Benedetti, Fabrizio, Demirkaya, Erkan, Foell, Dirk, Itoh, Yasuhiko ORCID: 0000-0002-4999-6473, Lahdenne, Pekka, Morgan, Esi M., Quartier, Pierre, Ruperto, Nicolino ORCID: 0000-0001-8407-7782, Russo, Ricardo ORCID: 0000-0002-1256-8483, Saad-Magalhaes, Claudia, Sawhney, Sujata, Scott, Christiaan, Shenoi, Susan, Swart, Joost F., Uziel, Yosef, Vastert, Sebastiaan J. and Smolen, Josef S. (2018). Treating juvenile idiopathic arthritis to target: recommendations of an international task force. Ann. Rheum. Dis., 77 (6). S. 819 - 829. LONDON: BMJ PUBLISHING GROUP. ISSN 1468-2060

Full text not available from this repository.

Abstract

Recent therapeutic advances in juvenile idiopathic arthritis (JIA) have made remission an achievable goal for most patients. Reaching this target leads to improved outcomes. The objective was to develop recommendations for treating JIA to target. A Steering Committee formulated a set of recommendations based on evidence derived from a systematic literature review. These were subsequently discussed, amended and voted on by an international Task Force of 30 paediatric rheumatologists in a consensus-based, Delphi-like procedure. Although the literature review did not reveal trials that compared a treat-to-target approach with another or no strategy, it provided indirect evidence regarding an optimised approach to therapy that facilitated development of recommendations. The group agreed on six overarching principles and eight recommendations. The main treatment target, which should be based on a shared decision with parents/patients, was defined as remission, with the alternative target of low disease activity. The frequency and timeline of follow-up evaluations to ensure achievement and maintenance of the target depend on JIA category and level of disease activity. Additional recommendations emphasise the importance of ensuring adequate growth and development and avoiding long-term systemic glucocorticoid administration to maintain the target. All items were agreed on by more than 80% of the members of the Task Force. A research agenda was formulated. The Task Force developed recommendations for treating JIA to target, being aware that the evidence is not strong and needs to be expanded by future research. These recommendations can inform various stakeholders about strategies to reach optimal outcomes for JIA.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Ravelli, AngeloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Consolaro, AlessandroUNSPECIFIEDorcid.org/0000-0002-0065-7614UNSPECIFIED
Horneff, GerdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laxer, Ronald M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lovell, Daniel J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wulffraat, Nico M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Akikusa, Jonathan D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Al-Mayouf, Sulaiman M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anton, JordiUNSPECIFIEDorcid.org/0000-0002-8792-4219UNSPECIFIED
Avcin, TadejUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berard, Roberta A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beresford, Michael W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burgos-Vargas, RubenUNSPECIFIEDorcid.org/0000-0003-1058-8955UNSPECIFIED
Cimaz, RolandoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Benedetti, FabrizioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Demirkaya, ErkanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Foell, DirkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Itoh, YasuhikoUNSPECIFIEDorcid.org/0000-0002-4999-6473UNSPECIFIED
Lahdenne, PekkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morgan, Esi M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Quartier, PierreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruperto, NicolinoUNSPECIFIEDorcid.org/0000-0001-8407-7782UNSPECIFIED
Russo, RicardoUNSPECIFIEDorcid.org/0000-0002-1256-8483UNSPECIFIED
Saad-Magalhaes, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sawhney, SujataUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scott, ChristiaanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shenoi, SusanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Swart, Joost F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Uziel, YosefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vastert, Sebastiaan J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smolen, Josef S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-185233
DOI: 10.1136/annrheumdis-2018-213030
Journal or Publication Title: Ann. Rheum. Dis.
Volume: 77
Number: 6
Page Range: S. 819 - 829
Date: 2018
Publisher: BMJ PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 1468-2060
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
OF-RHEUMATOLOGY RECOMMENDATIONS; INTERLEUKIN-1 RECEPTOR ANTAGONIST; MINIMAL DISEASE-ACTIVITY; CLINICAL REMISSION; DEFINING CRITERIA; INACTIVE DISEASE; DOUBLE-BLIND; DEVELOPING STANDARDS; SELECT CATEGORIES; ACTIVITY STATESMultiple languages
RheumatologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/18523

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item