Schwarz, C., Schulte-Hubbert, B., Bend, J., Abele-Horn, M., Baumann, I., Bremer, W., Brunsmann, F., Dieninghoff, D., Eickmeier, O., Ellemunter, H., Fischer, R., Grosse-Onnebrink, J., Hammermann, J., Hebestreit, H., Hogardt, M., Huegel, C., Hug, M., Illing, S., Jung, A., Kahl, B., Koitschev, A., Mahlberg, R., Mainz, J. G., Mattner, F., Mehl, A., Moeller, A., Muche-Borowski, C., Nuesslein, T., Puderbach, M., Renner, S., Rietschel, E., Ringshausen, F. C., Schmidt, S., Sedlacek, L., Sitter, H., Smaczny, C., Tuemmler, B., Vonberg, R., Wielpuetz, M. O., Wilkens, H., Wollschlaeger, B., Zerlik, J., Dueesberg, U. and van Koningsbruggen-Rietschel, S. (2018). CF Lung Disease - a German S3 Guideline: Module 2: Diagnostics and Treatment in Chronic Infection with Pseudomonas aeruginosa. Pneumologie, 72 (5). S. 347 - 393. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1438-8790

Full text not available from this repository.

Abstract

Cystic Fibrosis (CF) is the most common autosomal-recessive genetic disease affecting approximately 8000 people in Germany. The disease is caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene leading to dysfunction of CFTR, a transmembrane chloride channel. This defect causes insufficient hydration of the epithelial lining fluid which leads to chronic inflammation of the airways. Recurrent infections of the airways as well as pulmonary exacerbations aggravate chronic inflammation, lead to pulmonary fibrosis and tissue destruction up to global respiratory insufficiency, which is responsible for the mortality in over 90% of patients. The main aim of pulmonary treatment in CF is to reduce pulmonary inflammation and chronic infection. Pseudomonas aeruginosa ( Pa ) is the most relevant pathogen in the course of CF lung disease. Colonization and chronic infection are leading to additional loss of pulmonary function. There are many possibilities to treat Pa -infection. This is a S3-clinical guideline which implements a definition for chronic Pa -infection and demonstrates evidence-based diagnostic methods and medical treatment for Pa -infection in order to give guidance for individual treatment options.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Schwarz, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulte-Hubbert, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bend, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Abele-Horn, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baumann, I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bremer, W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brunsmann, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dieninghoff, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eickmeier, O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ellemunter, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fischer, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grosse-Onnebrink, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hammermann, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hebestreit, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hogardt, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huegel, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hug, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Illing, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jung, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kahl, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koitschev, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mahlberg, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mainz, J. G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mattner, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mehl, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moeller, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muche-Borowski, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nuesslein, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Puderbach, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Renner, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rietschel, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ringshausen, F. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sedlacek, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sitter, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smaczny, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tuemmler, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vonberg, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wielpuetz, M. O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wilkens, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wollschlaeger, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zerlik, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dueesberg, U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Koningsbruggen-Rietschel, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-187787
DOI: 10.1055/s-0044-100191
Journal or Publication Title: Pneumologie
Volume: 72
Number: 5
Page Range: S. 347 - 393
Date: 2018
Publisher: GEORG THIEME VERLAG KG
Place of Publication: STUTTGART
ISSN: 1438-8790
Language: German
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CYSTIC-FIBROSIS PATIENTS; TOBRAMYCIN INHALATION POWDER; INHALED AZTREONAM LYSINE; BRONCHIOLITIS OBLITERANS SYNDROME; DESORPTION IONIZATION-TIME; PULMONARY EXACERBATIONS; COMPUTED-TOMOGRAPHY; PARANASAL SINUSES; DOUBLE-BLIND; STAPHYLOCOCCUS-AUREUSMultiple languages
Respiratory SystemMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/18778

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item