Weymann, Alexander, Popov, Aron-Frederik ORCID: 0000-0003-4226-3004, Sabashnikov, Anton, Ali-Hasan-Al-Saegh, Sadeq ORCID: 0000-0001-6312-1705, Ryazanov, Mikhail, Tse, Gary ORCID: 0000-0001-5510-1253, Mirhosseini, Seyed Jalil, Liu, Tong, Lotfaliani, Mohammadreza, Sedaghat, Meghdad, Baker, William L., Ghanei, Azam, Yavuz, Senol ORCID: 0000-0001-5246-0808, Zeriouh, Mohamed, Izadpanah, Payman, Dehghan, Hamidreza, Testa, Luca, Nikfard, Maryam, Barros de Oliveira Sa, Michel Pompeu, Mashhour, Ahmed ORCID: 0000-0003-4496-3610, Nombela-Franco, Luis, Rezaeisadrabadi, Mohammad, D'Ascenzo, Fabrizio ORCID: 0000-0002-6646-9317, Zhigalov, Konstantin ORCID: 0000-0002-6440-3736, Benedetto, Umberto ORCID: 0000-0002-7074-7949, Najafi, Soroosh Aminolsharieh, Szczechowicz, Marcin, Roever, Leonardo, Meng, Lei, Gong, Mengqi, Deshmukh, Abhishek J., Palmerini, Tullio, Linde, Cecilia, Filipiak, Krzysztof J., Stone, Gregg W., Biondi-Zoccai, Giuseppe ORCID: 0000-0001-6103-8510 and Calkins, Hugh (2018). Baseline and postoperative levels of C-reactive protein and interleukins as inflammatory predictors of atrial fibrillation following cardiac surgery: a systematic review and meta-analysis. Kardiol. Pol., 76 (2). S. 440 - 452. WARSZAWA: POLSKIE TOWARZYSTOWO KARDIOLOGICZNE. ISSN 1897-4279

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Abstract

Background: Postoperative atrial fibrillation (POAF) is a leading arrhythmia with high incidence and serious clinical implications after cardiac surgery. Cardiac surgery is associated with systemic inflammatory response including increase in cytokines and activation of endothelial and leukocyte responses. Aim This systematic review and meta-analysis aimed to determine the strength of evidence for evaluating the association of inflammatory markers, such as C-reactive protein (CRP) and interleukins (IL), with POAF following isolated coronary artery bypass grafting (CABG), isolated valvular surgery, or a combination of these procedures. Methods: We conducted a meta-analysis of studies evaluating measured baseline (from one week before surgical procedures) and postoperative levels (until one week after surgical procedures) of inflammatory markers in patients with POAF. A comprehensive search was performed in electronic medical databases (Medline/PubMed, Web of Science, Embase, Science Direct, and Google Scholar) from their inception through May 2017 to identify relevant studies. A comprehensive subgroup analysis was performed to explore potential sources of heterogeneity. Results: A literature search of all major databases retrieved 1014 studies. After screening, 42 studies were analysed including a total of 8398 patients. Pooled analysis showed baseline levels of CRP (standard mean difference [SMD] 0.457 mg/L, p < 0.001), baseline levels of IL-6 (SMD 0.398 pg/mL, p < 0.001), postoperative levels of CRP (SMD 0.576 mg/L, p < 0.001), postoperative levels of IL-6 (SMD 1.66 pg/mL, p < 0.001), postoperative levels of IL-8 (SMD 0.839 pg/mL, p < 0.001), and postoperative levels of IL-10 (SMD 0.590 pg/mL, p < 0.001) to be relevant inflammatory parameters significantly associated with POAF. Conclusions: Perioperative inflammation is proposed to be involved in the pathogenesis of POAF. Therefore, perioperative assessment of CRP, IL-6, IL-8, and IL-10 can help clinicians in terms of predicting and monitoring for POAF.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Weymann, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Popov, Aron-FrederikUNSPECIFIEDorcid.org/0000-0003-4226-3004UNSPECIFIED
Sabashnikov, AntonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ali-Hasan-Al-Saegh, SadeqUNSPECIFIEDorcid.org/0000-0001-6312-1705UNSPECIFIED
Ryazanov, MikhailUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tse, GaryUNSPECIFIEDorcid.org/0000-0001-5510-1253UNSPECIFIED
Mirhosseini, Seyed JalilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liu, TongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lotfaliani, MohammadrezaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sedaghat, MeghdadUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baker, William L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ghanei, AzamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yavuz, SenolUNSPECIFIEDorcid.org/0000-0001-5246-0808UNSPECIFIED
Zeriouh, MohamedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Izadpanah, PaymanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dehghan, HamidrezaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Testa, LucaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nikfard, MaryamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barros de Oliveira Sa, Michel PompeuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mashhour, AhmedUNSPECIFIEDorcid.org/0000-0003-4496-3610UNSPECIFIED
Nombela-Franco, LuisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rezaeisadrabadi, MohammadUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
D'Ascenzo, FabrizioUNSPECIFIEDorcid.org/0000-0002-6646-9317UNSPECIFIED
Zhigalov, KonstantinUNSPECIFIEDorcid.org/0000-0002-6440-3736UNSPECIFIED
Benedetto, UmbertoUNSPECIFIEDorcid.org/0000-0002-7074-7949UNSPECIFIED
Najafi, Soroosh AminolshariehUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Szczechowicz, MarcinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roever, LeonardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meng, LeiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gong, MengqiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deshmukh, Abhishek J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Palmerini, TullioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Linde, CeciliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Filipiak, Krzysztof J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stone, Gregg W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Biondi-Zoccai, GiuseppeUNSPECIFIEDorcid.org/0000-0001-6103-8510UNSPECIFIED
Calkins, HughUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-200722
DOI: 10.5603/KP.a2017.0242
Journal or Publication Title: Kardiol. Pol.
Volume: 76
Number: 2
Page Range: S. 440 - 452
Date: 2018
Publisher: POLSKIE TOWARZYSTOWO KARDIOLOGICZNE
Place of Publication: WARSZAWA
ISSN: 1897-4279
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CORONARY-ARTERY-DISEASE; MEAN PLATELET VOLUME; CARDIOPULMONARY BYPASS; FATTY-ACIDS; NEW-ONSET; ASSOCIATION; SERUM; RISK; ACTIVATOR; MARKERMultiple languages
Cardiac & Cardiovascular SystemsMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/20072

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