Universität zu Köln

Buj, Christian, Muenter, Michael ORCID: 0000-0002-8004-3646, Schmarbeck, Benedikt, Horstmann, Jens, Huettmann, Gereon and Brinkmann, Ralf ORCID: 0000-0002-0445-8102 (2017). Noncontact holographic detection for photoacoustic tomography. J. Biomed. Opt., 22 (10). BELLINGHAM: SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS. ISSN 1560-2281

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Abstract

A holographic method for high-speed, noncontact photoacoustic tomography is introduced and evaluated. Relative changes of the object's topography, induced by the impact of thermoelastic pressure waves, were determined at nanometer sensitivity without physical contact. The object's surface was illuminated with nanosecond laser pulses and imaged with a high-speed CMOS camera. From two interferograms measured before and after excitation of the acoustic wave, surface displacement was calculated and then used as the basis for a tomographic reconstruction of the initial pressure caused by optical absorption. The holographic detection scheme enables variable sampling rates of the photoacoustic signal of up to 50 MHz. The total acquisition times for complete volumes with 230 MVoxel is far below 1 s. Measurements of silicone and porcine skin tissue phantoms with embedded artificial absorbers, which served as a model for human subcutaneous vascular networks, were possible. Three-dimensional reconstructions of the absorbing structures show details with a diameter of 310 aem up to a depth of 2.5 mm. Theoretical limitations and the experimental sensitivity, as well as the potential for in vivo imaging depending on the detection repetition rate, are analyzed and discussed. (C) 2017 Society of Photo-Optical Instrumentation Engineers (SPIE).

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Buj, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Muenter, Michael UNSPECIFIED orcid.org/0000-0002-8004-3646 UNSPECIFIED Schmarbeck, Benedikt UNSPECIFIED UNSPECIFIED UNSPECIFIED Horstmann, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Huettmann, Gereon UNSPECIFIED UNSPECIFIED UNSPECIFIED Brinkmann, Ralf UNSPECIFIED orcid.org/0000-0002-0445-8102 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-215562
DOI:	10.1117/1.JBO.22.10.106007
Journal or Publication Title:	J. Biomed. Opt.
Volume:	22
Number:	10
Date:	2017
Publisher:	SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
Place of Publication:	BELLINGHAM
ISSN:	1560-2281
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OFF-AXIS HOLOGRAPHY; ULTRASONIC-ATTENUATION; HUMAN SKIN; INTERFEROMETRY Multiple languages Biochemical Research Methods; Optics; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21556