Wilharm, Gottfried ORCID: 0000-0002-1771-6799, Skiebe, Evelyn, Higgins, Paul G. ORCID: 0000-0001-8677-9454, Poppel, Marie T., Blaschke, Ulrike ORCID: 0000-0002-3496-5447, Leser, Sarah, Heider, Christine, Heindorf, Magdalena, Brauner, Paul, Jaeckel, Udo, Boehland, Karin, Cuny, Christiane, Lopinska, Andzelina, Kaminski, Piotr, Kasprzak, Mariusz ORCID: 0000-0001-9088-8098, Bochenski, Marcin ORCID: 0000-0002-7081-809X, Ciebiera, Olaf, Tobolka, Marcin ORCID: 0000-0002-4989-1524, Zolnierowicz, Katarzyna M., Siekiera, Joachim, Seifert, Harald, Gagne, Stephanie, Salcedo, Suzana P., Kaatz, Michael, Layer, Franziska, Bender, Jennifer K., Fuchs, Stephan, Semmler, Torsten ORCID: 0000-0002-2225-7267, Pfeifer, Yvonne and Jerzak, Leszek (2017). Relatedness of wildlife and livestock avian isolates of the nosocomial pathogen Acinetobacter baumannii to lineages spread in hospitals worldwide. Environ. Microbiol., 19 (10). S. 4349 - 4365. HOBOKEN: WILEY. ISSN 1462-2920

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Abstract

The natural habitats and potential reservoirs of the nosocomial pathogen Acinetobacter baumannii are poorly defined. Here, we put forth and tested the hypothesis of avian reservoirs of A. baumannii. We screened tracheal and rectal swab samples from livestock (chicken, geese) and wild birds (white stork nestlings) and isolated A. baumannii from 3% of sampled chicken (n = 220), 8% of geese (n = 40) and 25% of white stork nestlings (n = 661). Virulence of selected avian A. baumannii isolates was comparable to that of clinical isolates in the Galleria mellonella infection model. Whole genome sequencing revealed the close relationship of an antibiotic-susceptible chicken isolate from Germany with a multidrug-resistant human clinical isolate from China and additional linkages between livestock isolates and human clinical isolates related to international clonal lineages. Moreover, we identified stork isolates related to human clinical isolates from the United States. Multilocus sequence typing disclosed further kinship between avian and human isolates. Avian isolates do not form a distinct clade within the phylogeny of A. baumannii, instead they diverge into different lineages. Further, we provide evidence that A. baumannii is constantly present in the habitats occupied by storks. Collectively, our study suggests A. baumannii could be a zoonotic organism that may disseminate into livestock.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Wilharm, GottfriedUNSPECIFIEDorcid.org/0000-0002-1771-6799UNSPECIFIED
Skiebe, EvelynUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Higgins, Paul G.UNSPECIFIEDorcid.org/0000-0001-8677-9454UNSPECIFIED
Poppel, Marie T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blaschke, UlrikeUNSPECIFIEDorcid.org/0000-0002-3496-5447UNSPECIFIED
Leser, SarahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heider, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heindorf, MagdalenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brauner, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaeckel, UdoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boehland, KarinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cuny, ChristianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lopinska, AndzelinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaminski, PiotrUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kasprzak, MariuszUNSPECIFIEDorcid.org/0000-0001-9088-8098UNSPECIFIED
Bochenski, MarcinUNSPECIFIEDorcid.org/0000-0002-7081-809XUNSPECIFIED
Ciebiera, OlafUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tobolka, MarcinUNSPECIFIEDorcid.org/0000-0002-4989-1524UNSPECIFIED
Zolnierowicz, Katarzyna M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Siekiera, JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seifert, HaraldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gagne, StephanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salcedo, Suzana P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaatz, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Layer, FranziskaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bender, Jennifer K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fuchs, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Semmler, TorstenUNSPECIFIEDorcid.org/0000-0002-2225-7267UNSPECIFIED
Pfeifer, YvonneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jerzak, LeszekUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-216446
DOI: 10.1111/1462-2920.13931
Journal or Publication Title: Environ. Microbiol.
Volume: 19
Number: 10
Page Range: S. 4349 - 4365
Date: 2017
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1462-2920
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SP-NOV; ANTIMICROBIAL RESISTANCE; MOLECULAR EPIDEMIOLOGY; STRAINS; IDENTIFICATION; SEQUENCE; OUTBREAK; PCR; ENVIRONMENTS; ASSOCIATIONMultiple languages
MicrobiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/21644

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