Universität zu Köln

Koy, Anne and Timmermann, Lars (2017). Deep brain stimulation in cerebral palsy: Challenges and opportunities. Eur. J. Paediatr. Neurol., 21 (1). S. 118 - 122. OXFORD: ELSEVIER SCI LTD. ISSN 1532-2130

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Abstract

Cerebral palsy (CP) is the most common cause for acquired dystonia in childhood. Phar-macological treatment is often unsatisfactory and side effects are frequently dose-limiting. Data on outcome of DBS in paediatric patients with dyskinetic CP is very limited and heterogeneous. Reasons for the variability in responses are not entirely known yet. Inter Accepted estingly, some CP-patients seem to improve subjectively on pallidal stimulation but without measurable changes in impairment scales. Besides dystonia scales, the use of sensitive age-dependent assessments tools is therefore reasonable to capture the full effect. As the course of disease duration as well as the age at operation seem to correlate with DBS outcome in patients with dystonia, DBS at an early stage of development might be beneficial for some of these patients. For the future, well-conducted trials as well as data collection in the international registry is of major importance to increase knowledge about DBS in CP patients, especially those implanted at a young age. Furthermore, selection criteria and guidelines or treatment standards are needed to improve the service for children with dyskinetic CP especially in light of unsatisfactory medical treatment options. (C) 2016 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Koy, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-243327
DOI:	10.1016/j.ejpn.2016.05.015
Journal or Publication Title:	Eur. J. Paediatr. Neurol.
Volume:	21
Number:	1
Page Range:	S. 118 - 122
Date:	2017
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1532-2130
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PALLIDAL STIMULATION; CHILDHOOD DYSTONIA; SECONDARY DYSTONIA; SEGMENTAL DYSTONIA; COGNITIVE FUNCTION; RATING-SCALE; YOUNG-ADULTS; CHILDREN; CHOREOATHETOSIS; METAANALYSIS Multiple languages Clinical Neurology; Pediatrics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24332