Universität zu Köln

Allanore, Yannick, Komocsi, Andras, Vettori, Serena ORCID: 0000-0001-5617-9829, Hachulla, Eric, Hunzelmann, Nicolas, Distler, Jorg, Avouac, Jerome, Gobeaux, Camille, Launay, David ORCID: 0000-0003-1840-1817, Czirjak, Laszlo, Kahan, Andre and Meune, Christophe (2016). N-terminal pro-brain natriuretic peptide is a strong predictor of mortality in systemic sclerosis. Int. J. Cardiol., 223. S. 385 - 390. CLARE: ELSEVIER IRELAND LTD. ISSN 1874-1754

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Abstract

Objectives: Cardiovascular involvement is a major contributor to mortality in systemic sclerosis (SSc). We examined whether N-terminal pro-brain natriuretic peptide (NT-proBNP) is a reliable predictor of mortality in SSc. Methods and results: This multicentre prospective cohort study included 523 patients presenting with SSc, whose mean age was 54 +/- 13 years, mean disease duration 8 +/- 9 years, and diffuse cutaneous form in 168. Plasma NT-proBNP was measured at baseline and the patients were followed yearly. Overall mortality was measured at 3 years. At baseline, cardiovascular involvement was present in 37 patients, including 17 with pulmonary artery hypertension (PAH) and 20 with a left ventricular ejection fraction (LVEF) <55%. At 3 years, 32 (7%) patients had died. The median [25th-75th percentile] NT-proBNP concentration was 203 ng/l [129-514] in patients who died within 3 years, versus 88 ng/l [47-167] in survivors (P < 0.001). NT-proBNP was an independent predictor of 3-years mortality in multivariate analysis (P = 0.046). The optimal cut-off derived from the ROC curve was 129 ng/l; sensitivity and specificity to predict 3 y mortality were 78.1 and 66.7%. Using the previously recommended 125-ng/l concentration as threshold value, NT-proBNP reliably and independently predicted 3 year mortality, with a sensitivity of 78.1 and a negative predictive value of 97.6%, respectively (P = 0.006). The consideration of SSc patients without PAH or LVEF < 55% at baseline yielded similar results. Conclusion: NT-proBNP appears as a reliable and independent predictor of mortality in patients with SSc. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Allanore, Yannick UNSPECIFIED UNSPECIFIED UNSPECIFIED Komocsi, Andras UNSPECIFIED UNSPECIFIED UNSPECIFIED Vettori, Serena UNSPECIFIED orcid.org/0000-0001-5617-9829 UNSPECIFIED Hachulla, Eric UNSPECIFIED UNSPECIFIED UNSPECIFIED Hunzelmann, Nicolas UNSPECIFIED UNSPECIFIED UNSPECIFIED Distler, Jorg UNSPECIFIED UNSPECIFIED UNSPECIFIED Avouac, Jerome UNSPECIFIED UNSPECIFIED UNSPECIFIED Gobeaux, Camille UNSPECIFIED UNSPECIFIED UNSPECIFIED Launay, David UNSPECIFIED orcid.org/0000-0003-1840-1817 UNSPECIFIED Czirjak, Laszlo UNSPECIFIED UNSPECIFIED UNSPECIFIED Kahan, Andre UNSPECIFIED UNSPECIFIED UNSPECIFIED Meune, Christophe UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-255668
DOI:	10.1016/j.ijcard.2016.08.246
Journal or Publication Title:	Int. J. Cardiol.
Volume:	223
Page Range:	S. 385 - 390
Date:	2016
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1874-1754
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PULMONARY ARTERIAL-HYPERTENSION; 5-YEAR SURVIVAL; SCLERODERMA; COHORT; COMPLICATIONS; DISEASE; MODEL Multiple languages Cardiac & Cardiovascular Systems Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25566