Jakob, Carolin E. M., Borgmann, Stefan, Duygu, Fazilet, Behrends, Uta, Hower, Martin, Merle, Uta, Friedrichs, Anette, Tometten, Lukas, Hanses, Frank, Jung, Norma, Rieg, Siegbert ORCID: 0000-0001-7493-7080, Wille, Kai ORCID: 0000-0002-7682-8563, Gruener, Beate, Klinker, Hartwig, Gersbacher-Runge, Nicole, Hellwig, Kerstin, Eberwein, Lukas, Dolff, Sebastian, Rauschning, Dominic, von Bergwelt-Baildon, Michael, Lanznaster, Julia, Strauss, Richard, Trauth, Janina, de With, Katja, Ruethrich, Maria, Lueck, Catherina, Nattermann, Jacob, Tscharntke, Lene, Pilgram, Lisa, Fuhrmann, Sandra, Classen, Annika, Stecher, Melanie, Schons, Maximilian, Spinner, Christoph ORCID: 0000-0002-3875-5367 and Vehreschild, Joerg Janne . First results of the Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS). Infection. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1439-0973

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Abstract

Purpose Knowledge regarding patients' clinical condition at severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection is sparse. Data in the international, multicenter Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS) cohort study may enhance the understanding of COVID-19. Methods Sociodemographic and clinical characteristics of SARS-CoV-2-infected patients, enrolled in the LEOSS cohort study between March 16, 2020, and May 14, 2020, were analyzed. Associations between baseline characteristics and clinical stages at diagnosis (uncomplicated vs. complicated) were assessed using logistic regression models. Results We included 2155 patients, 59.7% (1,287/2,155) were male; the most common age category was 66-85 years (39.6%; 500/2,155). The primary COVID-19 diagnosis was made in 35.0% (755/2,155) during complicated clinical stages. A significant univariate association between age; sex; body mass index; smoking; diabetes; cardiovascular, pulmonary, neurological, and kidney diseases; ACE inhibitor therapy; statin intake and an increased risk for complicated clinical stages of COVID-19 at diagnosis was found. Multivariable analysis revealed that advanced age [46-65 years: adjusted odds ratio (aOR): 1.73, 95% CI 1.25-2.42,p = 0.001; 66-85 years: aOR 1.93, 95% CI 1.36-2.74,p < 0.001; > 85 years: aOR 2.38, 95% CI 1.49-3.81,p < 0.001 vs. individuals aged 26-45 years], male sex (aOR 1.23, 95% CI 1.01-1.50,p = 0.040), cardiovascular disease (aOR 1.37, 95% CI 1.09-1.72,p = 0.007), and diabetes (aOR 1.33, 95% CI 1.04-1.69,p = 0.023) were associated with complicated stages of COVID-19 at diagnosis. Conclusion The LEOSS cohort identified age, cardiovascular disease, diabetes and male sex as risk factors for complicated disease stages at SARS-CoV-2 diagnosis, thus confirming previous data. Further data regarding outcomes of the natural course of COVID-19 and the influence of treatment are required.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Jakob, Carolin E. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borgmann, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duygu, FaziletUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Behrends, UtaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hower, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Merle, UtaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Friedrichs, AnetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tometten, LukasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hanses, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jung, NormaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rieg, SiegbertUNSPECIFIEDorcid.org/0000-0001-7493-7080UNSPECIFIED
Wille, KaiUNSPECIFIEDorcid.org/0000-0002-7682-8563UNSPECIFIED
Gruener, BeateUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klinker, HartwigUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gersbacher-Runge, NicoleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hellwig, KerstinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eberwein, LukasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dolff, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rauschning, DominicUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Bergwelt-Baildon, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lanznaster, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Strauss, RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trauth, JaninaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de With, KatjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruethrich, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lueck, CatherinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nattermann, JacobUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tscharntke, LeneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pilgram, LisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fuhrmann, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Classen, AnnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stecher, MelanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schons, MaximilianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spinner, ChristophUNSPECIFIEDorcid.org/0000-0002-3875-5367UNSPECIFIED
Vehreschild, Joerg JanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-317553
DOI: 10.1007/s15010-020-01499-0
Journal or Publication Title: Infection
Publisher: SPRINGER HEIDELBERG
Place of Publication: HEIDELBERG
ISSN: 1439-0973
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Infectious DiseasesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31755

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