Universität zu Köln

Hahn, Luisa, Helmrich, Nora, Herebian, Diran ORCID: 0000-0002-8528-0122, Mayatepek, Ertan, Drebber, Uta, Domann, Eugen, Olejniczak, Stefan, Weigel, Markus ORCID: 0000-0002-3140-3174, Hain, Torsten, Rath, Timo, Wirtz, Stefan, Mollenkopf, Hans-Joachim, Schmidt, Nadine, Ewers, Christa, Baier, Anne, Churin, Yuri, Windhorst, Anita, Weiskirchen, Ralf, Steinhoff, Ulrich, Roeb, Elke and Roderfeld, Martin (2020). IL-13 as Target to Reduce Cholestasis and Dysbiosis inAbcb4Knockout Mice. Cells, 9 (9). BASEL: MDPI. ISSN 2073-4409

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Abstract

The Th2 cytokine IL-13 is involved in biliary epithelial injury and liver fibrosis in patients as well as in animal models. The aim of this study was to investigate IL-13 as a therapeutic target during short term and chronic intrahepatic cholestasis in anAbcb4-knockout mouse model (Abcb4(-/-)). Lack of IL-13 protectedAbcb4(-/-)mice transiently from cholestasis. This decrease in serum bile acids was accompanied by an enhanced excretion of bile acids and a normalization of fecal bile acid composition. InAbcb4(-/-)/IL-13(-/-)double knockout mice, bacterial translocation to the liver was significantly reduced and the intestinal microbiome resembled the commensal composition in wild type animals. In addition, 52-week-oldAbcb4(-/-)IL-13(-/-)mice showed significantly reduced hepatic fibrosis.Abcb4(-/-)mice devoid of IL-13 transiently improved cholestasis and converted the composition of the gut microbiota towards healthy conditions. This highlights IL-13 as a potential therapeutic target in biliary diseases.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hahn, Luisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Helmrich, Nora UNSPECIFIED UNSPECIFIED UNSPECIFIED Herebian, Diran UNSPECIFIED orcid.org/0000-0002-8528-0122 UNSPECIFIED Mayatepek, Ertan UNSPECIFIED UNSPECIFIED UNSPECIFIED Drebber, Uta UNSPECIFIED UNSPECIFIED UNSPECIFIED Domann, Eugen UNSPECIFIED UNSPECIFIED UNSPECIFIED Olejniczak, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Weigel, Markus UNSPECIFIED orcid.org/0000-0002-3140-3174 UNSPECIFIED Hain, Torsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Rath, Timo UNSPECIFIED UNSPECIFIED UNSPECIFIED Wirtz, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Mollenkopf, Hans-Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Nadine UNSPECIFIED UNSPECIFIED UNSPECIFIED Ewers, Christa UNSPECIFIED UNSPECIFIED UNSPECIFIED Baier, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Churin, Yuri UNSPECIFIED UNSPECIFIED UNSPECIFIED Windhorst, Anita UNSPECIFIED UNSPECIFIED UNSPECIFIED Weiskirchen, Ralf UNSPECIFIED UNSPECIFIED UNSPECIFIED Steinhoff, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Roeb, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED Roderfeld, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-320294
DOI:	10.3390/cells9091949
Journal or Publication Title:	Cells
Volume:	9
Number:	9
Date:	2020
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2073-4409
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NECROSIS-FACTOR-ALPHA; PRIMARY BILIARY-CIRRHOSIS; BILE-ACIDS; SCLEROSING CHOLANGITIS; HEPATIC-FIBROSIS; TIGHT JUNCTIONS; BACTERIAL TRANSLOCATION; EPITHELIAL-CELLS; LIVER-INJURY; INTERLEUKIN-13 Multiple languages Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32029