Abrahamyan, Sargis, Eberspaecher, Bettina, Hoshi, Muna-Miriam, Aly, Lilian, Luessi, Felix, Groppa, Sergiu ORCID: 0000-0002-2551-5655, Klotz, Luisa, Meuth, Sven G., Schroeder, Christoph, Grueter, Thomas, Tackenberg, Bjoern, Paul, Friedemann, Then-Bergh, Florian, Kuempfel, Tania, Weber, Frank, Stangel, Martin, Bayas, Antonios, Wildemann, Brigitte, Heesen, Christoph, Zettl, Uwe, Warnke, Clemens, Antony, Gisela, Hessler, Nicole, Wiendl, Heinz, Bittner, Stefan, Hemmer, Bernhard, Gold, Ralf, Salmen, Anke and Ruprecht, Klemens (2020). Complete Epstein-Barr virus seropositivity in a large cohort of patients with early multiple sclerosis. J. Neurol. Neurosurg. Psychiatry, 91 (7). S. 681 - 687. LONDON: BMJ PUBLISHING GROUP. ISSN 1468-330X

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Abstract

Objective To determine the prevalence of antibodies to Epstein-Barr virus (EBV) in a large cohort of patients with early multiple sclerosis (MS). Methods Serum samples were collected from 901 patients with a clinically isolated syndrome (CIS) or early relapsing-remitting multiple sclerosis (RRMS) participating in the German National MS cohort, a prospective cohort of patients with early MS with stringent inclusion criteria. Epstein-Barr nuclear antigen (EBNA)-1 and viral capsid antigen (VCA) antibodies were measured in diluted sera by chemiluminescence immunoassays (CLIAs). Sera of EBNA-1 and VCA antibody-negative patients were retested undiluted by an EBV IgG immunoblot. For comparison, we retrospectively analysed the EBV seroprevalence across different age cohorts, ranging from 0 to >80 years, in a large hospital population (N=16 163) from Berlin/Northern Germany. Results EBNA-1 antibodies were detected by CLIA in 839 of 901 patients with CIS/RRMS. Of the 62 patients without EBNA-1 antibodies, 45 had antibodies to VCA as detected by CLIA. In all of the remaining 17 patients, antibodies to EBV were detected by immunoblot. Altogether, 901 of 901 (100%) patients with CIS/RRMS were EBV-seropositive. EBV seropositivity increased with age in the hospital population but did not reach 100% in any of the investigated age cohorts. Conclusion The complete EBV seropositivity in this large cohort of patients with early MS strengthens the evidence for a role of EBV in MS. It also suggests that a negative EBV serology in patients with suspected inflammatory central nervous system disease should alert clinicians to consider diagnoses other than MS.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Abrahamyan, SargisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eberspaecher, BettinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoshi, Muna-MiriamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aly, LilianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luessi, FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Groppa, SergiuUNSPECIFIEDorcid.org/0000-0002-2551-5655UNSPECIFIED
Klotz, LuisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meuth, Sven G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schroeder, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grueter, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tackenberg, BjoernUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paul, FriedemannUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Then-Bergh, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuempfel, TaniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weber, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stangel, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bayas, AntoniosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wildemann, BrigitteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heesen, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zettl, UweUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Warnke, ClemensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antony, GiselaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hessler, NicoleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiendl, HeinzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bittner, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hemmer, BernhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gold, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salmen, AnkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruprecht, KlemensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-328028
DOI: 10.1136/jnnp-2020-322941
Journal or Publication Title: J. Neurol. Neurosurg. Psychiatry
Volume: 91
Number: 7
Page Range: S. 681 - 687
Date: 2020
Publisher: BMJ PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 1468-330X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ENVIRONMENTAL RISK-FACTORS; INFECTION; PREVENTION; EBVMultiple languages
Clinical Neurology; Psychiatry; SurgeryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/32802

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