Universität zu Köln

Pelzer, Esther A., Pauls, K. Amande M., Braun, Nina, Tittgemeyer, Marc and Timmermann, Lars (2020). Probabilistic tractography in the ventrolateral thalamic nucleus: cerebellar and pallidal connections. Brain Struct. Funct., 225 (5). S. 1685 - 1690. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1863-2661

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Abstract

The ventrolateral thalamic nucleus (VL), as part of the 'motor thalamus', is main relay station of cerebellar and pallidal projections. It comprises anterior (VLa) and posterior (VLpd and VLpv) subnuclei. Though the fibre architecture of cerebellar and pallidal projections to of the VL nucleus has already been focus in a numerous amount of in vitro studies mainly in animals, probabilistic tractography now offers the possibility of an in vivo comparison in healthy humans. In this study we performed a (a) qualitative and (b) quantitative examination of VL-cerebellar and VL-pallidal pathways and compared the probability distributions between both projection fields in the VL after an (I) atlas-based and (II) manual-based segmentation procedure. Both procedures led to high congruent results of cerebellar and pallidal connectivity distributions: the maximum of pallidal projections was located in anterior and medial parts of the VL nucleus, whereas cerebellar connectivity was more located in lateral and posterior parts. The median connectivity for cerebellar connections in both approaches (manual and atlas-based segmentation) was VLa > VLpv > VLpd, whereas the pallidal median connectivity was VLa VLpv > VLpd in the atlas-based approach and VLpv > VLa > VLpd in the manual approach.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pelzer, Esther A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pauls, K. Amande M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Braun, Nina UNSPECIFIED UNSPECIFIED UNSPECIFIED Tittgemeyer, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-334505
DOI:	10.1007/s00429-020-02076-9
Journal or Publication Title:	Brain Struct. Funct.
Volume:	225
Number:	5
Page Range:	S. 1685 - 1690
Date:	2020
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1863-2661
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VENTRALIS INTERMEDIUS NUCLEUS; MOTOR THALAMUS; STIMULATION; MONKEY Multiple languages Anatomy & Morphology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33450