Neumaier, Felix ORCID: 0000-0002-6376-6391, Schneider, Toni ORCID: 0000-0003-2816-2696 and Albanna, Walid (2020). Ca(v)2.3 channel function and Zn2+-induced modulation: potential mechanisms and (patho)physiological relevance. Channels, 14 (1). S. 362 - 380. PHILADELPHIA: TAYLOR & FRANCIS INC. ISSN 1933-6969

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Abstract

Voltage-gated calcium channels (VGCCs) are critical for Ca(2+)influx into all types of excitable cells, but their exact function is still poorly understood. Recent reconstruction of homology models for all human VGCCs at atomic resolution provides the opportunity for a structure-based discussion of VGCC function and novel insights into the mechanisms underlying Ca(2+)selective flux through these channels. In the present review, we use these data as a basis to examine the structure, function, and Zn2+-induced modulation of Ca(v)2.3 VGCCs, which mediate native R-type currents and belong to the most enigmatic members of the family. Their unique sensitivity to Zn(2+)and the existence of multiple mechanisms of Zn(2+)action strongly argue for a role of these channels in the modulatory action of endogenous loosely bound Zn2+, pools of which have been detected in a number of neuronal, endocrine, and reproductive tissues. Following a description of the different mechanisms by which Zn(2+)has been shown or is thought to alter the function of these channels, we discuss their potential (patho)physiological relevance, taking into account what is known about the magnitude and function of extracellular Zn(2+)signals in different tissues. While still far from complete, the picture that emerges is one where Ca(v)2.3 channel expression parallels the occurrence of loosely bound Zn(2+)pools in different tissues and where these channels may serve to translate physiological Zn(2+)signals into changes of electrical activity and/or intracellular Ca(2+)levels.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Neumaier, FelixUNSPECIFIEDorcid.org/0000-0002-6376-6391UNSPECIFIED
Schneider, ToniUNSPECIFIEDorcid.org/0000-0003-2816-2696UNSPECIFIED
Albanna, WalidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-349866
DOI: 10.1080/19336950.2020.1829842
Journal or Publication Title: Channels
Volume: 14
Number: 1
Page Range: S. 362 - 380
Date: 2020
Publisher: TAYLOR & FRANCIS INC
Place of Publication: PHILADELPHIA
ISSN: 1933-6969
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SYNAPTICALLY-RELEASED ZINC; GATED CA2+ CHANNEL; SINGLE CALCIUM CHANNELS; HIPPOCAMPAL MOSSY FIBERS; LONG-TERM POTENTIATION; SMOOTH-MUSCLE-CELLS; R-TYPE; MICE LACKING; GLUCAGON-RELEASE; HIGH-VOLTAGEMultiple languages
Biochemistry & Molecular BiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/34986

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