Bergami, Matteo ORCID: 0000-0001-5525-5025, Masserdotti, Giacomo, Temprana, Silvio G., Motori, Elisa, Eriksson, Therese M., Goebel, Jana, Yang, Sung Min, Conzelmann, Karl-Klaus ORCID: 0000-0002-8614-3656, Schinder, Alejandro F., Goetz, Magdalena and Berninger, Benedikt ORCID: 0000-0003-2652-2782 (2015). A Critical Period for Experience-Dependent Remodeling of Adult-Born Neuron Connectivity. Neuron, 85 (4). S. 710 - 718. CAMBRIDGE: CELL PRESS. ISSN 1097-4199

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Abstract

Neurogenesis in the dentate gyrus (DG) of the adult hippocampus is a process regulated by experience. To understand whether experience also modifies the connectivity of new neurons, we systematically investigated changes in their innervation following environmental enrichment (EE). We found that EE exposure between 2-6 weeks following neuron birth, rather than merely increasing the number of new neurons, profoundly affected their pattern of monosynaptic inputs. Both local innervation by interneurons and to even greater degree long-distance innervation by cortical neurons were markedly enhanced. Furthermore, following EE, new neurons received inputs from CA3 and CA1 inhibitory neurons that were rarely observed under control conditions. While EE-induced changes in inhibitory innervation were largely transient, cortical innervation remained increased after returning animals to control conditions. Our findings demonstrate an unprecedented experience-dependent reorganization of connections impinging onto adult-born neurons, which is likely to have important impact on their contribution to hippocampal information processing.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bergami, MatteoUNSPECIFIEDorcid.org/0000-0001-5525-5025UNSPECIFIED
Masserdotti, GiacomoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Temprana, Silvio G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Motori, ElisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eriksson, Therese M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goebel, JanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yang, Sung MinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Conzelmann, Karl-KlausUNSPECIFIEDorcid.org/0000-0002-8614-3656UNSPECIFIED
Schinder, Alejandro F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goetz, MagdalenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berninger, BenediktUNSPECIFIEDorcid.org/0000-0003-2652-2782UNSPECIFIED
URN: urn:nbn:de:hbz:38-412260
DOI: 10.1016/j.neuron.2015.01.001
Journal or Publication Title: Neuron
Volume: 85
Number: 4
Page Range: S. 710 - 718
Date: 2015
Publisher: CELL PRESS
Place of Publication: CAMBRIDGE
ISSN: 1097-4199
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ENHANCED SYNAPTIC PLASTICITY; GENERATED GRANULE CELLS; DENTATE GYRUS; HIPPOCAMPAL NEUROGENESIS; PATTERN SEPARATION; RABIES VIRUS; INTEGRATION; ACTIVATION; MATURATION; BEHAVIORMultiple languages
NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/41226

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