Universität zu Köln

Bercsenyi, Kinga ORCID: 0000-0001-5730-9752, Schmieg, Nathalie, Bryson, J. Barney, Wallace, Martin, Caccin, Paola, Golding, Matthew, Zanotti, Giuseppe, Greensmith, Linda, Nischt, Roswitha and Schiavo, Giampietro (2014). Nidogens are therapeutic targets for the prevention of tetanus. Science, 346 (6213). S. 1118 - 1124. WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE. ISSN 1095-9203

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Abstract

T cell responses are initiated by antigen and promoted by a range of costimulatory signals. Understanding how T cells integrate alternative signal combinations and make decisions affecting immune response strength or tolerance poses a considerable theoretical challenge. Here, we report that T cell receptor (TCR) and costimulatory signals imprint an early, cell-intrinsic, division fate, whereby cells effectively count through generations before returning automatically to a quiescent state. This autonomous program can be extended by cytokines. Signals from the TCR, costimulatory receptors, and cytokines add together using a linear division calculus, allowing the strength of a T cell response to be predicted from the sum of the underlying signal components. These data resolve a long-standing costimulation paradox and provide a quantitative paradigm for therapeutically manipulating immune response strength.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bercsenyi, Kinga UNSPECIFIED orcid.org/0000-0001-5730-9752 UNSPECIFIED Schmieg, Nathalie UNSPECIFIED UNSPECIFIED UNSPECIFIED Bryson, J. Barney UNSPECIFIED UNSPECIFIED UNSPECIFIED Wallace, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Caccin, Paola UNSPECIFIED UNSPECIFIED UNSPECIFIED Golding, Matthew UNSPECIFIED UNSPECIFIED UNSPECIFIED Zanotti, Giuseppe UNSPECIFIED UNSPECIFIED UNSPECIFIED Greensmith, Linda UNSPECIFIED UNSPECIFIED UNSPECIFIED Nischt, Roswitha UNSPECIFIED UNSPECIFIED UNSPECIFIED Schiavo, Giampietro UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-422967
DOI:	10.1126/science.1258138
Journal or Publication Title:	Science
Volume:	346
Number:	6213
Page Range:	S. 1118 - 1124
Date:	2014
Publisher:	AMER ASSOC ADVANCEMENT SCIENCE
Place of Publication:	WASHINGTON
ISSN:	1095-9203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BOTULINUM NEUROTOXIN-B; PROTEIN-RECEPTOR; BINDING-SITE; MATRIX; AFFINITY; DEFECTS; COMPLEX; LAMININ Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42296