Universität zu Köln

Rovituso, Damiano, Heller, Stefanie, Schroeter, Michael, Kleinschnitz, Christoph ORCID: 0000-0002-1650-8875 and Kuerten, Stefanie (2014). B1 cells are unaffected by immune modulatory treatment in remitting-relapsing multiple sclerosis patients. J. Neuroimmunol., 272 (1-2). S. 86 - 91. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1872-8421

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Abstract

In this study we aimed to investigate whether treatment with an immune modulatory drug had an effect on the distribution of B cell subpopulations in patients with remitting-relapsing multiple sclerosis (RRMS). We investigated the first-line drugs glatiramer acetate, interferon-beta and natalizumab. Our data show that the frequency of the CD27(+)CD43(+) B1 cell subset was significantly diminished in RRMS patients compared to healthy subjects and that this subset was unaffected by treatment. Regardless of their true nature, we believe that these cells are part of the autoimmune disease pattern. (C) 2014 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rovituso, Damiano UNSPECIFIED UNSPECIFIED UNSPECIFIED Heller, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroeter, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Kleinschnitz, Christoph UNSPECIFIED orcid.org/0000-0002-1650-8875 UNSPECIFIED Kuerten, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-433871
DOI:	10.1016/j.jneuroim.2014.04.008
Journal or Publication Title:	J. Neuroimmunol.
Volume:	272
Number:	1-2
Page Range:	S. 86 - 91
Date:	2014
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	1872-8421
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MEMORY; SUBPOPULATION Multiple languages Immunology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43387