Worm, Margitta ORCID: 0000-0002-3449-1245, Eckermann, Oliver, Doelle, Sabine, Aberer, Werner, Beyer, Kirsten, Hawranek, Thomas, Hompes, Stephanie, Koehli, Alice, Mahler, Vera, Nemat, Katja, Niggemann, Bodo, Pfoehler, Claudia, Rabe, Uta, Reissig, Angelika, Rietschel, Ernst, Scherer, Kathrin, Treudler, Regina and Rueff, Franziska (2014). Triggers and Treatment of Anaphylaxis An Analysis of 4000 Cases From Germany, Austria and Switzerland. Dtsch. Arztebl. Int., 111 (21). S. 367 - 378. COLOGNE: DEUTSCHER AERZTE-VERLAG GMBH. ISSN 1866-0452

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Abstract

Background: Anaphylaxis is the most severe manifestation of a mast cell-dependent immediate reaction and may be fatal. According to data from the Berlin region, its incidence is 2-3 cases per 100 000 persons per year. Methods: We evaluated data from the anaphylaxis registry of the German-speaking countries for 2006-2013 and data from the protocols of the ADAC air rescue service for 2010-2011 to study the triggers, clinical manifestations, and treatment of anaphylaxis. Results: The registry contained data on 4141 patients, and the ADAC air rescue protocols concerned 1123 patients. In the registry, the most common triggers for anaphylaxis were insect venom (n = 2074; 50.1%), foods (n = 1039; 25.1%), and drugs (n = 627; 15.1%). Within these groups, the most common triggers were wasp (n = 1460) and bee stings (n = 412), legumes (n = 241), animal proteins (n = 225), and analgesic drugs (n = 277). Food anaphylaxis was most frequently induced by peanuts, cow milk, and hen's egg in children and by wheat and shellfish in adults. An analysis of the medical emergency cases revealed that epinephrine was given for grade 3 or 4 anaphylaxis to 14.5% and 43.9% (respectively) of the patients in the anaphylaxis registry and to 19% and 78% of the patients in the air rescue protocols. Conclusion: Wasp and bee venom, legumes, animal proteins, and analgesic drugs were the commonest triggers of anaphylaxis. Their relative frequency was age-dependent. Epinephrine was given too rarely, as it is recommended in the guidelines for all cases of grade 2 and above.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Worm, MargittaUNSPECIFIEDorcid.org/0000-0002-3449-1245UNSPECIFIED
Eckermann, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Doelle, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aberer, WernerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beyer, KirstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hawranek, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hompes, StephanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koehli, AliceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mahler, VeraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nemat, KatjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Niggemann, BodoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfoehler, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rabe, UtaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reissig, AngelikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rietschel, ErnstUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scherer, KathrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Treudler, ReginaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rueff, FranziskaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-437744
DOI: 10.3238/arztebl.2014.0367
Journal or Publication Title: Dtsch. Arztebl. Int.
Volume: 111
Number: 21
Page Range: S. 367 - 378
Date: 2014
Publisher: DEUTSCHER AERZTE-VERLAG GMBH
Place of Publication: COLOGNE
ISSN: 1866-0452
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
WORLD-ALLERGY-ORGANIZATION; FOOD; EPIDEMIOLOGY; TRENDSMultiple languages
Medicine, General & InternalMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/43774

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