Kye, Min Jeong ORCID: 0000-0002-1323-7256 and Goncalves, Ines do Carmo G. (2014). The role of rniRNA in motor neuron disease. Front. Cell. Neurosci., 8. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1662-5102

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Abstract

microRNA is a subset of endogenous non-coding RNA. It binds to partially complementary sequences in mRNAs and inhibits mRNA translation by either blocking translational machinery or degrading mRNAs. It is involved in various cellular processes including cell cycle, development, metabolism, and synaptic plasticity. Dysregulation of miRNA expression and function is reported in various diseases including cancer, metabolic disorders as well as neurological disorders. In nervous system, miRNA related pathways play a very important role in development and function of neuronal cells. Moreover, numerous evidences suggest that dysregulated miRNA related pathways contribute to pathology of neurological disorders such as Alzheimer's disease, amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). Here, we review current knowledge about the role of miRNAs in motor neuron disorders, especially about two common diseases: SMA and ALS.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kye, Min JeongUNSPECIFIEDorcid.org/0000-0002-1323-7256UNSPECIFIED
Goncalves, Ines do Carmo G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-448051
DOI: 10.3389/fncel.2014.00015
Journal or Publication Title: Front. Cell. Neurosci.
Volume: 8
Date: 2014
Publisher: FRONTIERS MEDIA SA
Place of Publication: LAUSANNE
ISSN: 1662-5102
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SPINAL MUSCULAR-ATROPHY; MESSENGER-RNA; MICRORNA BIOGENESIS; TRANSLATIONAL REPRESSION; HEXANUCLEOTIDE REPEAT; FUNCTIONAL RECOVERY; PROTEIN INTERACTS; CORD-INJURY; GENE; SMNMultiple languages
NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/44805

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