Universität zu Köln

Balasso, Andrea, Bauer, Jan S., Liebig, Thomas, Dorn, Franziska ORCID: 0000-0001-9093-8307, Zimmer, Claus, Liepsch, Dieter and Prothmann, Sascha (2014). Evaluation of intra-aneurysmal hemodynamics after flow diverter placement in a patient-specific aneurysm model. Biorheology, 51 (6). S. 341 - 355. AMSTERDAM: IOS PRESS. ISSN 1878-5034

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Abstract

BACKGROUND: The growth and rupture of cerebral aneurysms is intrinsically related to the hemodynamics prevailing in the diseased area. Therefore, a better understanding of intra-aneurysmal hemodynamics is essential for developing effective treatment methods. OBJECTIVE: The intention of this study was to evaluate the intra-aneurysmal flow and flow reduction induced by flow diverters in a true-to-scale elastic aneurysm model, obtained from real patient data. METHODS: Based on the computed tomography angiography (CTA) data of a fusiform aneurysm of a 34 year old patient, an elastic silicon rubber model of the aneurysm was produced. A physiologic pulsatile flow was created with a circulatory experimental set-up, and a non-Newtonian perfusion fluid was used as a substitute for human blood. Hemodynamics were measured by LDA before and after flow diverter implantation. RESULTS: Implantation of a flow diverter device resulted in a reduction of intra-aneurysmal maximum flow velocities of 97.8% at the inflow zone, 89.1% in the dome and 89.3% at the outflow zone, when compared to the native model. A significant reduction of 94% in the mean intra-aneurysmal velocity was found. CONCLUSIONS: This promising methodology can optimize patient treatment and will correlate with computational simulations to evaluate their reliability.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Balasso, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Bauer, Jan S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Liebig, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Dorn, Franziska UNSPECIFIED orcid.org/0000-0001-9093-8307 UNSPECIFIED Zimmer, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Liepsch, Dieter UNSPECIFIED UNSPECIFIED UNSPECIFIED Prothmann, Sascha UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-448932
DOI:	10.3233/BIR-14019
Journal or Publication Title:	Biorheology
Volume:	51
Number:	6
Page Range:	S. 341 - 355
Date:	2014
Publisher:	IOS PRESS
Place of Publication:	AMSTERDAM
ISSN:	1878-5034
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PIPELINE EMBOLIZATION DEVICE; INTRACRANIAL ANEURYSMS; ENDOVASCULAR TREATMENT; SACCULAR ANEURYSMS; STENT; ARTERY; RECONSTRUCTION; THROMBOSIS; RUPTURE; STRESS Multiple languages Biophysics; Engineering, Biomedical; Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44893