Drexelius, Marco G. and Neundorf, Ines ORCID: 0000-0001-6450-3991 (2021). Application of Antimicrobial Peptides on Biomedical Implants: Three Ways to Pursue Peptide Coatings. Int. J. Mol. Sci., 22 (24). BASEL: MDPI. ISSN 1422-0067

Full text not available from this repository.

Abstract

Biofilm formation and inflammations are number one reasons of implant failure and cause a severe number of postoperative complications every year. To functionalize implant surfaces with antibiotic agents provides perspectives to minimize and/or prevent bacterial adhesion and proliferation. In recent years, antimicrobial peptides (AMP) have been evolved as promising alternatives to commonly used antibiotics, and have been seen as potent candidates for antimicrobial surface coatings. This review aims to summarize recent developments in this field and to highlight examples of the most common techniques used for preparing such AMP-based medical devices. We will report on three different ways to pursue peptide coatings, using either binding sequences (primary approach), linker layers (secondary approach), or loading in matrixes which offer a defined release (tertiary approach). All of them will be discussed in the light of current research in this area.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Drexelius, Marco G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neundorf, InesUNSPECIFIEDorcid.org/0000-0001-6450-3991UNSPECIFIED
URN: urn:nbn:de:hbz:38-563006
DOI: 10.3390/ijms222413212
Journal or Publication Title: Int. J. Mol. Sci.
Volume: 22
Number: 24
Date: 2021
Publisher: MDPI
Place of Publication: BASEL
ISSN: 1422-0067
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ANTIBACTERIAL ACTIVITY; CALCIUM-PHOSPHATE; CHIMERIC PEPTIDES; TIO2 NANOTUBES; IN-VITRO; TITANIUM; SURFACE; IMMOBILIZATION; INTEGRATION; INHIBITIONMultiple languages
Biochemistry & Molecular Biology; Chemistry, MultidisciplinaryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/56300

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item