Karapanos, Leonidas ORCID: 0000-0001-7608-7673, Akbarov, Ilgar ORCID: 0000-0002-1487-8696, Zugor, Vahudin, Kokx, Ruud, Hagemeier, Anna and Heidenreich, Axel (2021). Safety and mid-term surgical results of anterior urethroplasty with the tissue-engineered oral mucosa graft MukoCell(R): A single-center experience. Int. J. Urol., 28 (9). S. 936 - 943. HOBOKEN: WILEY. ISSN 1442-2042

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Abstract

Objective To assess the mid-term efficacy and safety of anterior urethroplasty using an autologous tissue-engineered oral mucosa graft (MukoCell(R)). Methods The data of 77 patients with anterior urethral strictures undergoing treatment with MukoCell(R) at a tertiary center from June 2016 to May 2019 were analyzed. Patients' characteristics, pre- and postoperative diagnostics, perioperative complications, and follow-up data were obtained. The overall stricture-free survival, outcomes of the different surgical techniques, stricture localizations, stricture length, early complications of the procedure and risk factors of recurrence were assessed. Results The median follow-up period was 38 months (interquartile range 31-46). The overall recurrence-free rate of anterior urethroplasty using MukoCell(R) was 68.8%, 24 patients (31.2%) developed a recurrence of the stricture. The stricture recurrences were observed at a median of 7 months (interquartile range 3-13) only in patients with at least one previous surgery or repeated dilatations in their medical history. No oral-urethral adverse events related to the use of MukoCell(R) were observed, except for a urethrocutaneous fistula (1.3%) requiring reoperation. Conclusions Anterior one-stage urethroplasty using MukoCell(R) showed in our hands a mid-term success rate of up to 68.8% without significant adverse events after a median follow-up period of 38 months. This procedure might be an alternative option for long-segment urethral reconstruction.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Karapanos, LeonidasUNSPECIFIEDorcid.org/0000-0001-7608-7673UNSPECIFIED
Akbarov, IlgarUNSPECIFIEDorcid.org/0000-0002-1487-8696UNSPECIFIED
Zugor, VahudinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kokx, RuudUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hagemeier, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heidenreich, AxelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-576836
DOI: 10.1111/iju.14606
Journal or Publication Title: Int. J. Urol.
Volume: 28
Number: 9
Page Range: S. 936 - 943
Date: 2021
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1442-2042
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
URETHRAL STRICTURE; AUTOLOGOUS GRAFT; HYPOSPADIAS; DISEASEMultiple languages
Urology & NephrologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/57683

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