Universität zu Köln

Stinnesbeck, Melissa, Kristiansen, Anna, Ellinger, Joerg, Hauser, Stefan, Egevad, Lars, Tolkach, Yuri and Kristiansen, Glen (2021). Prognostic role of TSPAN1, KIAA1324 and ESRP1 in prostate cancer. APMIS, 129 (4). S. 204 - 213. HOBOKEN: WILEY. ISSN 1600-0463

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Abstract

The aim of this study was to validate prostate cancer-associated genes on transcript level and to assess the prognostic value of the most promising markers by immunohistochemistry. Based on differentially expressed genes found in a previous study, 84 genes were further validated using mRNA expression data and follow-up information from the Cancer Genome Atlas (TCGA) prostate cancer cohort (n = 497). Immunohistochemistry was used for validation of three genes in an independent, clinically annotated prostatectomy patient cohort (n = 175) with biochemical relapse as endpoint. Also, associations with clinicopathological variables were evaluated. Eleven protein-coding genes from the list of 84 genes were associated with biochemical recurrence-free survival on mRNA expression level in multivariate Cox-analyses. Three of these genes (TSPAN1, ESRP1 and KIAA1324) were immunohistochemically validated using an independent cohort of prostatectomy patients. Both ESRP1 and KIAA1324 were independently associated with biochemical recurrence-free survival. TSPAN1 was univariately prognostic but failed significance on multivariate analysis, probably due to its strong correlation with high Gleason scores. Multistep filtering using the publicly available TCGA cohort, data of an earlier expression profiling study which profiled 3023 cancer-associated transcripts in 42 primary prostate cancer cases, identified two novel candidate prognostic markers (ESRP1 and KIAA1324) of primary prostate cancer for further study.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Stinnesbeck, Melissa UNSPECIFIED UNSPECIFIED UNSPECIFIED Kristiansen, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Ellinger, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Hauser, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Egevad, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Tolkach, Yuri UNSPECIFIED UNSPECIFIED UNSPECIFIED Kristiansen, Glen UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-578151
DOI:	10.1111/apm.13117
Journal or Publication Title:	APMIS
Volume:	129
Number:	4
Page Range:	S. 204 - 213
Date:	2021
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1600-0463
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Immunology; Microbiology; Pathology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57815