Oberste, Max, Pusch, Lynn-Marie, Roth, Rebecca, Shah-Hosseini, Kija ORCID: 0000-0001-9616-6942, Dewald, Felix, Mueller, Claudia, von Goltzheim, Luise Stach, Lehmann, Clara, Buess, Michael, Wolff, Anna, Faetkenheuer, Gerd, Wiesmueller, Gerhard, Klein, Florian, Hellmich, Martin and Neuhann, Florian (2021). Protocol of the Cologne Corona Surveillance (CoCoS) Study- a prospective population-based cohort study. BMC Public Health, 21 (1). LONDON: BMC. ISSN 1471-2458

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Abstract

BackgroundSurveillance strategies are critical to cope with the current SARS-CoV-2 pandemic and to evaluate, as well as adjust government-imposed countermeasures. Incidence estimates are widely based on laboratory confirmed cases reported by health authorities. Prevalence and incidence data of SARS-CoV-2 is still scarce, along with demographic and behavioural factors associated with infection risk.MethodsThe Cologne Corona Surveillance Study will be conducted in the City of Cologne, which is the fourth-largest city in Germany with a population of approximately 1.1 million. Researchers will apply self-sampling surveillance to a rolling cohort of Cologne residents. Random samples of 6000 Cologne residents 18years of age and older will be drawn from the registration office. Upon receiving the information and saliva sample kit, participants will be asked to fill out a questionnaire online or via phone, sign written informed consent, and send back written consent, as well as saliva sample. The saliva samples will be tested for SARS-CoV-2 by reverse PCR. The questionnaire will be administered to gather information about personal characteristics such as health status and risks. A second round of testing will take place 6 weeks after the first.DiscussionSelf-administered saliva sampling proved to be a legitimate and feasible alternative to nasopharyngeal swabs taken by health professionals. However, it is unclear whether the targeted response rate of 40% can be achieved and whether the results are representative of the population.Trial registrationDRKS.de, German Clinical Trials Register (DRKS), Identifier: DRKS00024046, Registered on 25 February 2021.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Oberste, MaxUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pusch, Lynn-MarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roth, RebeccaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shah-Hosseini, KijaUNSPECIFIEDorcid.org/0000-0001-9616-6942UNSPECIFIED
Dewald, FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Goltzheim, Luise StachUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lehmann, ClaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buess, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolff, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Faetkenheuer, GerdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiesmueller, GerhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klein, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hellmich, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neuhann, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-578782
DOI: 10.1186/s12889-021-11206-9
Journal or Publication Title: BMC Public Health
Volume: 21
Number: 1
Date: 2021
Publisher: BMC
Place of Publication: LONDON
ISSN: 1471-2458
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Public, Environmental & Occupational HealthMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/57878

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