Wunsch, Stefanie, Zurl, Christoph ORCID: 0000-0003-0623-0360, Strohmaier, Heimo, Meinitzer, Andreas, Rabensteiner, Jasmin, Posch, Wilfried ORCID: 0000-0001-8955-7654, Lass-Floerl, Cornelia, Cornely, Oliver, Pregartner, Gudrun, Koenig, Elisabeth, Feierl, Gebhard, Hoenigl, Martin ORCID: 0000-0002-1653-2824, Prattes, Juergen ORCID: 0000-0001-5751-9311, Zollner-Schwetz, Ines, Valentin, Thomas and Krause, Robert (2021). Longitudinal Evaluation of Plasma Cytokine Levels in Patients with Invasive Candidiasis. J. Fungi, 7 (2). BASEL: MDPI. ISSN 2309-608X

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Abstract

Interleukin (IL) 17A plays a decisive role in anti-Candida host defense. Previous data demonstrated significantly increased IL-17A values in candidemic patients. We evaluated levels and time courses of IL-17A, and other cytokines suggested to be involved in Candida-specific immunity (IL-6, IL-8, IL-10, IL-17F, IL-22, IL-23, interferon-gamma, tumor necrosis factor-alpha, Pentraxin-related protein 3, transforming growth factor-beta) in patients with invasive candidiasis (IC) compared to bacteremic patients (Staphylococcus aureus, Escherichia coli) and healthy controls (from previous 4 days up to day 14 relative to the index culture (-4; 14)). IL-17A levels were significantly elevated in all groups compared to healthy controls. In IC, the highest IL-17A values were measured around the date of index sampling (-1; 2), compared to significantly lower levels prior and after sampling the index culture. Candidemic patients showed significantly higher IL-17A values compared to IC other than candidemia at time interval (-1; 2) and (3; 7). No significant differences in IL-17A levels could be observed for IC compared to bacteremic patients. Candidemic patients had higher IL-8, IL-10, IL-22, IFN-gamma, PTX3 and TNF-alpha values compared to non-candidemic. Based on the limited discriminating competence between candidemia and bacteremia, IL-17A has to be considered a biomarker for blood stream infection rather than invasive Candida infection.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Wunsch, StefanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zurl, ChristophUNSPECIFIEDorcid.org/0000-0003-0623-0360UNSPECIFIED
Strohmaier, HeimoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meinitzer, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rabensteiner, JasminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Posch, WilfriedUNSPECIFIEDorcid.org/0000-0001-8955-7654UNSPECIFIED
Lass-Floerl, CorneliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cornely, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pregartner, GudrunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koenig, ElisabethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Feierl, GebhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoenigl, MartinUNSPECIFIEDorcid.org/0000-0002-1653-2824UNSPECIFIED
Prattes, JuergenUNSPECIFIEDorcid.org/0000-0001-5751-9311UNSPECIFIED
Zollner-Schwetz, InesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Valentin, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krause, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-590823
DOI: 10.3390/jof7020101
Journal or Publication Title: J. Fungi
Volume: 7
Number: 2
Date: 2021
Publisher: MDPI
Place of Publication: BASEL
ISSN: 2309-608X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
HOST-DEFENSE; CANDIDEMIA; DIAGNOSIS; IL-17; INFECTIONS; MORTALITY; IMMUNITY; ALBICANS; OUTCOMES; THERAPYMultiple languages
Microbiology; MycologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/59082

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