Hujer, Andrea M., Hujer, Kristine M., Leonard, David A., Powers, Rachel A., Wallar, Bradley J., Mack, Andrew R., Taracila, Magdalena A., Rather, Philip N., Higgins, Paul G. ORCID: 0000-0001-8677-9454, Prati, Fabio ORCID: 0000-0002-0650-9540, Caselli, Emilia ORCID: 0000-0002-7248-9453, Marshall, Steven H., Clarke, Thomas, Greco, Christopher, Venepally, Pratap, Brinkac, Lauren, Kreiswirth, Barry N., Fouts, Derrick E. and Bonomo, Robert A. (2021). A comprehensive and contemporary snapshot of beta-lactamases in carbapenem resistant Acinetobacter baumannii. Diagn. Microbiol. Infect. Dis., 99 (2). NEW YORK: ELSEVIER SCIENCE INC. ISSN 1879-0070

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Abstract

Successful treatment of Acinetobacter baumannii infections require early and appropriate antimicrobial therapy. One of the first steps in this process is understanding which beta-lactamase (bla) alleles are present and in what combinations. Thus, we performed WGS on 98 carbapenem-resistant A. baumannii (CR Ab). In most isolates, an acquired bla(OXA) carbapenemase was found in addition to the intrinsic bla(OXA) allele. The most commonly found allele was bla(OXA-23) (n = 78/98). In some isolates, bla(OXA-23) was found in addition to other carbapenemase alleles: bla(OXA-82) (n = 12/78), bla(OXA-72) (n = 2/78) and bla(OXA-24/40) (n = 1/78). Surprisingly, 20% of isolates carried carbapenemases not routinely assayed for by rapid molecular diagnostic platforms, i.e., bla(OXA-82) and bla(OXA-172); all had ISAba1 elements. In 8 CR Ab, bla(OXA-82) or bla(OXA-172) was the only carbapenemase. Both bla(OXA-24/40) and its variant bla(OXA-72) were each found in 6/98 isolates. The most prevalent ADC variants were bla(ADC-30) (21%), bla(ADC-162) (21%), and bla(ADC-212) (26%). Complete combinations are reported. Published by Elsevier Inc.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Hujer, Andrea M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hujer, Kristine M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leonard, David A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Powers, Rachel A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wallar, Bradley J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mack, Andrew R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Taracila, Magdalena A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rather, Philip N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Higgins, Paul G.UNSPECIFIEDorcid.org/0000-0001-8677-9454UNSPECIFIED
Prati, FabioUNSPECIFIEDorcid.org/0000-0002-0650-9540UNSPECIFIED
Caselli, EmiliaUNSPECIFIEDorcid.org/0000-0002-7248-9453UNSPECIFIED
Marshall, Steven H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Clarke, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Greco, ChristopherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Venepally, PratapUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brinkac, LaurenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kreiswirth, Barry N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fouts, Derrick E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bonomo, Robert A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-601501
DOI: 10.1016/j.diagmicrobio.2020.115242
Journal or Publication Title: Diagn. Microbiol. Infect. Dis.
Volume: 99
Number: 2
Date: 2021
Publisher: ELSEVIER SCIENCE INC
Place of Publication: NEW YORK
ISSN: 1879-0070
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SPREAD; OXA-24; CEPHALOSPORINASE; ASSOCIATION; PNEUMONIA; VARIANTS; GENES; SPP.; PCRMultiple languages
Infectious Diseases; MicrobiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60150

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