Rosen, Marlene, Betz, Linda T., Kaiser, Natalie, Penzel, Nora, Dwyer, Dominic, Lichtenstein, Theresa K., Schultze-Lutter, Frauke ORCID: 0000-0003-1956-9574, Kambeitz-Ilankovic, Lana, Bertolino, Alessandro, Borgwardt, Stefan, Brambilla, Paolo, Lencer, Rebekka, Meisenzahl, Eva, Pantelis, Christos, Salokangas, Raimo K. R., Upthegrove, Rachel ORCID: 0000-0001-8204-5103, Wood, Stephen, Ruhrmann, Stephan, Koutsouleris, Nikolaos and Kambeitz, Joseph . Detailed clinical phenotyping and generalisability in prognostic models of functioning in at-risk populations. Br. J. Psychiatry. CAMBRIDGE: CAMBRIDGE UNIV PRESS. ISSN 1472-1465

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Abstract

Personalised prediction of functional outcomes is a promising approach for targeted early intervention in psychiatry. However, generalisability and resource efficiency of such prognostic models represent challenges. In the PRONIA study (German Clinical Trials Register: DRKS00005042), we demonstrate excellent generalisability of prognostic models in individuals at clinical high-risk for psychosis or with recent-onset depression, and substantial contributions of detailed clinical phenotyping, particularly to the prediction of role functioning. These results indicate that it is possible that functioning prediction models based only on clinical data could be effectively applied in diverse healthcare settings, so that neuroimaging data may not be needed at early assessment stages.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Rosen, MarleneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Betz, Linda T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaiser, NatalieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Penzel, NoraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dwyer, DominicUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lichtenstein, Theresa K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schultze-Lutter, FraukeUNSPECIFIEDorcid.org/0000-0003-1956-9574UNSPECIFIED
Kambeitz-Ilankovic, LanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bertolino, AlessandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borgwardt, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brambilla, PaoloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lencer, RebekkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meisenzahl, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pantelis, ChristosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salokangas, Raimo K. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Upthegrove, RachelUNSPECIFIEDorcid.org/0000-0001-8204-5103UNSPECIFIED
Wood, StephenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruhrmann, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koutsouleris, NikolaosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kambeitz, JosephUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-604295
DOI: 10.1192/bjp.2021.141
Journal or Publication Title: Br. J. Psychiatry
Publisher: CAMBRIDGE UNIV PRESS
Place of Publication: CAMBRIDGE
ISSN: 1472-1465
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
INDIVIDUALS; PSYCHOSISMultiple languages
PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60429

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