Pagano, Livio, Salmanton-Garcia, Jon, Marchesi, Francesco ORCID: 0000-0001-6353-2272, Busca, Alessandro, Corradini, Paolo, Hoenigl, Martin ORCID: 0000-0002-1653-2824, Klimko, Nikolai, Koehler, Philipp ORCID: 0000-0002-7386-7495, Pagliuca, Antonio, Passamonti, Francesco ORCID: 0000-0001-8068-5289, Verga, Luisa, Visek, Benjamin, Ilhan, Osman, Nadali, Gianpaolo, Weinbergerova, Barbora, Cordoba-Mascunano, Raul, Marchetti, Monia, Collins, Graham P., Farina, Francesca, Cattaneo, Chiara, Cabirta, Alba ORCID: 0000-0001-7198-8894, Gomes-Silva, Maria, Itri, Federico ORCID: 0000-0002-3532-5281, van Doesum, Jaap, Ledoux, Marie-Pierre, Cernan, Martin, Jaksic, Ozren, Duarte, Rafael F., Magliano, Gabriele, Omrani, Ali S., Fracchiolla, Nicola S., Kulasekararaj, Austin, Valkovic, Toni, Poulsen, Christian Bjorn, Machado, Marina ORCID: 0000-0002-8370-2248, Glenthoj, Andreas, Stoma, Igor ORCID: 0000-0003-0483-7329, Racil, Zdenek, Piukovics, Klara, Navratil, Milan, Emarah, Ziad ORCID: 0000-0003-0622-2598, Sili, Uluhan, Maertens, Johan, Blennow, Ola ORCID: 0000-0002-7167-7882, Bergantim, Rui, Garcia-Vidal, Carolina, Prezioso, Lucia ORCID: 0000-0003-1660-4960, Guidetti, Anna, del Principe, Maria Ilaria, Popova, Marina, de Jonge, Nick, Ormazabal-Velez, Irati, Fernandez, Noemi, Falces-Romero, Iker, Cuccaro, Annarosa, Meers, Stef, Buquicchio, Caterina, Antic, Darko, Al-Khabori, Murtadha, Garcia-Sanz, Ramon ORCID: 0000-0003-4120-2787, Biernat, Monika M., Tisi, Maria Chiara, Sal, Ertan ORCID: 0000-0003-2761-2675, Rahimli, Laman, Colovic, Natasa, Schonlein, Martin, Calbacho, Maria, Tascini, Carlo, Miranda-Castillo, Carolina, Khanna, Nina, Mendez, Gustavo-Adolfo, Petzer, Verena, Novak, Jan, Besson, Caroline, Dulery, Remy, Lamure, Sylvain, Nucci, Marcio, Zambrotta, Giovanni, Zak, Pavel, Seval, Guldane Cengiz, Bonuomo, Valentina, Mayer, Jiri, Lopez-Garcia, Alberto, Sacchi, Maria Vittoria, Booth, Stephen, Ciceri, Fabio, Oberti, Margherita, Salvini, Marco, Izuzquiza, Macarena, Nunes-Rodrigues, Raquel, Ammatuna, Emanuele, Obr, Ales, Herbrecht, Raoul, Nunez-Martin-Buitrago, Lucia, Mancini, Valentina, Shwaylia, Hawraa, Sciume, Mariarita, Essame, Jenna, Nygaard, Marietta, Batinic, Josip, Gonzaga, Yung ORCID: 0000-0003-1416-2118, Regalado-Artamendi, Isabel ORCID: 0000-0002-9673-9015, Karlsson, Linda Katharina ORCID: 0000-0003-3317-7550, Shapetska, Maryia, Hanakova, Michaela, El-Ashwah, Shaimaa, Borbenyi, Zita, Colak, Gokce Melis, Nordlander, Anna, Dragonetti, Giulia, Maraglino, Alessio Maria Edoardo, Rinaldi, Amelia, De Ramon-Sanchez, Cristina and Cornely, Oliver A. (2021). COVID-19 infection in adult patients with hematological malignancies: a European Hematology Association Survey (EPICOVIDEHA). J. Hematol. Oncol., 14 (1). LONDON: BMC. ISSN 1756-8722

Full text not available from this repository.

Abstract

Background Patients with hematological malignancies (HM) are at high risk of mortality from SARS-CoV-2 disease 2019 (COVID-19). A better understanding of risk factors for adverse outcomes may improve clinical management in these patients. We therefore studied baseline characteristics of HM patients developing COVID-19 and analyzed predictors of mortality. Methods The survey was supported by the Scientific Working Group Infection in Hematology of the European Hematology Association (EHA). Eligible for the analysis were adult patients with HM and laboratory-confirmed COVID-19 observed between March and December 2020. Results The study sample includes 3801 cases, represented by lymphoproliferative (mainly non-Hodgkin lymphoma n = 1084, myeloma n = 684 and chronic lymphoid leukemia n = 474) and myeloproliferative malignancies (mainly acute myeloid leukemia n = 497 and myelodysplastic syndromes n = 279). Severe/critical COVID-19 was observed in 63.8% of patients (n = 2425). Overall, 2778 (73.1%) of the patients were hospitalized, 689 (18.1%) of whom were admitted to intensive care units (ICUs). Overall, 1185 patients (31.2%) died. The primary cause of death was COVID-19 in 688 patients (58.1%), HM in 173 patients (14.6%), and a combination of both COVID-19 and progressing HM in 155 patients (13.1%). Highest mortality was observed in acute myeloid leukemia (199/497, 40%) and myelodysplastic syndromes (118/279, 42.3%). The mortality rate significantly decreased between the first COVID-19 wave (March-May 2020) and the second wave (October-December 2020) (581/1427, 40.7% vs. 439/1773, 24.8%, p value < 0.0001). In the multivariable analysis, age, active malignancy, chronic cardiac disease, liver disease, renal impairment, smoking history, and ICU stay correlated with mortality. Acute myeloid leukemia was a higher mortality risk than lymphoproliferative diseases. Conclusions This survey confirms that COVID-19 patients with HM are at high risk of lethal complications. However, improved COVID-19 prevention has reduced mortality despite an increase in the number of reported cases.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Pagano, LivioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salmanton-Garcia, JonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marchesi, FrancescoUNSPECIFIEDorcid.org/0000-0001-6353-2272UNSPECIFIED
Busca, AlessandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Corradini, PaoloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoenigl, MartinUNSPECIFIEDorcid.org/0000-0002-1653-2824UNSPECIFIED
Klimko, NikolaiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koehler, PhilippUNSPECIFIEDorcid.org/0000-0002-7386-7495UNSPECIFIED
Pagliuca, AntonioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Passamonti, FrancescoUNSPECIFIEDorcid.org/0000-0001-8068-5289UNSPECIFIED
Verga, LuisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Visek, BenjaminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ilhan, OsmanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nadali, GianpaoloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weinbergerova, BarboraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cordoba-Mascunano, RaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marchetti, MoniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Collins, Graham P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Farina, FrancescaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cattaneo, ChiaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cabirta, AlbaUNSPECIFIEDorcid.org/0000-0001-7198-8894UNSPECIFIED
Gomes-Silva, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Itri, FedericoUNSPECIFIEDorcid.org/0000-0002-3532-5281UNSPECIFIED
van Doesum, JaapUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ledoux, Marie-PierreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cernan, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaksic, OzrenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duarte, Rafael F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Magliano, GabrieleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Omrani, Ali S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fracchiolla, Nicola S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kulasekararaj, AustinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Valkovic, ToniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Poulsen, Christian BjornUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Machado, MarinaUNSPECIFIEDorcid.org/0000-0002-8370-2248UNSPECIFIED
Glenthoj, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stoma, IgorUNSPECIFIEDorcid.org/0000-0003-0483-7329UNSPECIFIED
Racil, ZdenekUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Piukovics, KlaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Navratil, MilanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Emarah, ZiadUNSPECIFIEDorcid.org/0000-0003-0622-2598UNSPECIFIED
Sili, UluhanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maertens, JohanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blennow, OlaUNSPECIFIEDorcid.org/0000-0002-7167-7882UNSPECIFIED
Bergantim, RuiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia-Vidal, CarolinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prezioso, LuciaUNSPECIFIEDorcid.org/0000-0003-1660-4960UNSPECIFIED
Guidetti, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
del Principe, Maria IlariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Popova, MarinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Jonge, NickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ormazabal-Velez, IratiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fernandez, NoemiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Falces-Romero, IkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cuccaro, AnnarosaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meers, StefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buquicchio, CaterinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antic, DarkoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Al-Khabori, MurtadhaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia-Sanz, RamonUNSPECIFIEDorcid.org/0000-0003-4120-2787UNSPECIFIED
Biernat, Monika M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tisi, Maria ChiaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sal, ErtanUNSPECIFIEDorcid.org/0000-0003-2761-2675UNSPECIFIED
Rahimli, LamanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Colovic, NatasaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schonlein, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Calbacho, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tascini, CarloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Miranda-Castillo, CarolinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khanna, NinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mendez, Gustavo-AdolfoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Petzer, VerenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Novak, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Besson, CarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dulery, RemyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lamure, SylvainUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nucci, MarcioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zambrotta, GiovanniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zak, PavelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seval, Guldane CengizUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bonuomo, ValentinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mayer, JiriUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lopez-Garcia, AlbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sacchi, Maria VittoriaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Booth, StephenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ciceri, FabioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oberti, MargheritaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salvini, MarcoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Izuzquiza, MacarenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nunes-Rodrigues, RaquelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ammatuna, EmanueleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Obr, AlesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herbrecht, RaoulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nunez-Martin-Buitrago, LuciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mancini, ValentinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shwaylia, HawraaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sciume, MariaritaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Essame, JennaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nygaard, MariettaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Batinic, JosipUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gonzaga, YungUNSPECIFIEDorcid.org/0000-0003-1416-2118UNSPECIFIED
Regalado-Artamendi, IsabelUNSPECIFIEDorcid.org/0000-0002-9673-9015UNSPECIFIED
Karlsson, Linda KatharinaUNSPECIFIEDorcid.org/0000-0003-3317-7550UNSPECIFIED
Shapetska, MaryiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hanakova, MichaelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
El-Ashwah, ShaimaaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borbenyi, ZitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Colak, Gokce MelisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nordlander, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dragonetti, GiuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maraglino, Alessio Maria EdoardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rinaldi, AmeliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Ramon-Sanchez, CristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cornely, Oliver A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-608375
DOI: 10.1186/s13045-021-01177-0
Journal or Publication Title: J. Hematol. Oncol.
Volume: 14
Number: 1
Date: 2021
Publisher: BMC
Place of Publication: LONDON
ISSN: 1756-8722
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CANCERMultiple languages
Oncology; HematologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60837

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