Chatzikonstantinou, Thomas, Kapetanakis, Anargyros, Scarfo, Lydia, Karakatsoulis, Georgios, Allsup, David ORCID: 0000-0001-6159-6109, Alonso Cabrero, Alejandro, Andres, Martin ORCID: 0000-0001-9891-2988, Antic, Darko, Baile, Monica, Baliakas, Panagiotis, Bron, Dominique, Capasso, Antonella, Chatzileontiadou, Sofia, Cordoba, Raul, Correa, Juan-Gonzalo, Cuellar-Garcia, Carolina, De Paoli, Lorenzo, De Paolis, Maria Rosaria, Del Poeta, Giovanni, Demosthenous, Christos, Dimou, Maria, Donaldson, David, Doubek, Michael, Efstathopoulou, Maria, Eichhorst, Barbara, El-Ashwah, Shaimaa, Enrico, Alicia, Espinet, Blanca ORCID: 0000-0002-4294-8145, Farina, Lucia, Ferrari, Angela, Foglietta, Myriam, Frederiksen, Henrik ORCID: 0000-0001-8905-0220, Furstenau, Moritz, Garcia-Marco, Jose A., Garcia-Serra, Rocio, Gentile, Massimo, Gimeno, Eva, Glenthoj, Andreas, da Silva, Maria Gomes, Gutwein, Odit, Hakobyan, Yervand K., Herishanu, Yair, Angel Hernandez-Rivas, Jose, Herold, Tobias ORCID: 0000-0002-9615-9432, Innocenti, Idanna, Itchaki, Gilad, Jaksic, Ozren, Janssens, Ann, Kalashnikova, Olga B., Kalicinska, Elzbieta ORCID: 0000-0002-4797-8001, Karlsson, Linda Katharina, Kater, Arnon P., Kersting, Sabina, Labrador, Jorge, Lad, Deepesh ORCID: 0000-0003-3754-7774, Laurenti, Luca, Levin, Mark-David, Lista, Enrico, Lopez-Garcia, Alberto, Malerba, Lara, Marasca, Roberto, Marchetti, Monia, Marquet, Juan, Mattsson, Mattias, Mauro, Francesca R., Milosevic, Ivana, Miras, Fatima, Morawska, Marta ORCID: 0000-0001-6836-2903, Motta, Marina, Munir, Talha, Murru, Roberta, Niemann, Carsten U., Rodrigues, Raquel Nunes, Olivieri, Jacopo, Orsucci, Lorella, Papaioannou, Maria, Arturo Pavlovsky, Miguel, Piskunova, Inga, Popov, Viola Maria, Quaglia, Francesca Maria, Quaresmini, Giulia, Qvist, Kristian, Reda, Gianluigi, Rigolin, Gian Matteo, Ruchlemer, Rosa, Saghumyan, Gevorg, Shrestha, Amit, Simkovic, Martin ORCID: 0000-0003-0331-5334, Spacek, Martin, Sportoletti, Paolo, Stanca, Oana, Stavroyianni, Niki, Tadmor, Tamar, Te Raa, Doreen, Tonino, Sanne H., Trentin, Livio, Van der Spek, Ellen, van Gelder, Michel, van Kampen, Roel, Varettoni, Marzia, Visentin, Andrea ORCID: 0000-0003-0271-7200, Vitale, Candida, Wasik-Szczepanek, Ewa, Wrobel, Tomasz ORCID: 0000-0002-6612-3535, Yanez San Segundo, Lucrecia, Yassin, Mohamed, Coscia, Marta, Rambaldi, Alessandro, Montserrat, Emili, Foa, Robin, Cuneo, Antonio, Stamatopoulos, Kostas and Ghia, Paolo (2021). COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study. Leukemia, 35 (12). S. 3444 - 3455. LONDON: SPRINGERNATURE. ISSN 1476-5551

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Abstract

Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to Coronavirus disease 2019 (COVID-19) due to age, disease, and treatment-related immunosuppression. We aimed to assess risk factors of outcome and elucidate the impact of CLL-directed treatments on the course of COVID-19. We conducted a retrospective, international study, collectively including 941 patients with CLL and confirmed COVID-19. Data from the beginning of the pandemic until March 16, 2021, were collected from 91 centers. The risk factors of case fatality rate (CFR), disease severity, and overall survival (OS) were investigated. OS analysis was restricted to patients with severe COVID-19 (definition: hospitalization with need of oxygen or admission into an intensive care unit). CFR in patients with severe COVID-19 was 38.4%. OS was inferior for patients in all treatment categories compared to untreated (p < 0.001). Untreated patients had a lower risk of death (HR = 0.54, 95% CI:0.41-0.72). The risk of death was higher for older patients and those suffering from cardiac failure (HR = 1.03, 95% CI:1.02-1.04; HR = 1.79, 95% CI:1.04-3.07, respectively). Age, CLL-directed treatment, and cardiac failure were significant risk factors of OS. Untreated patients had a better chance of survival than those on treatment or recently treated.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Chatzikonstantinou, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kapetanakis, AnargyrosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scarfo, LydiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karakatsoulis, GeorgiosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Allsup, DavidUNSPECIFIEDorcid.org/0000-0001-6159-6109UNSPECIFIED
Alonso Cabrero, AlejandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andres, MartinUNSPECIFIEDorcid.org/0000-0001-9891-2988UNSPECIFIED
Antic, DarkoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baile, MonicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baliakas, PanagiotisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bron, DominiqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Capasso, AntonellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chatzileontiadou, SofiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cordoba, RaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Correa, Juan-GonzaloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cuellar-Garcia, CarolinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Paoli, LorenzoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Paolis, Maria RosariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Del Poeta, GiovanniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Demosthenous, ChristosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dimou, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Donaldson, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Doubek, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Efstathopoulou, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eichhorst, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
El-Ashwah, ShaimaaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Enrico, AliciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Espinet, BlancaUNSPECIFIEDorcid.org/0000-0002-4294-8145UNSPECIFIED
Farina, LuciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ferrari, AngelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Foglietta, MyriamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frederiksen, HenrikUNSPECIFIEDorcid.org/0000-0001-8905-0220UNSPECIFIED
Furstenau, MoritzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia-Marco, Jose A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia-Serra, RocioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gentile, MassimoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gimeno, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glenthoj, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
da Silva, Maria GomesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gutwein, OditUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hakobyan, Yervand K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herishanu, YairUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Angel Hernandez-Rivas, JoseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herold, TobiasUNSPECIFIEDorcid.org/0000-0002-9615-9432UNSPECIFIED
Innocenti, IdannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Itchaki, GiladUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaksic, OzrenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Janssens, AnnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kalashnikova, Olga B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kalicinska, ElzbietaUNSPECIFIEDorcid.org/0000-0002-4797-8001UNSPECIFIED
Karlsson, Linda KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kater, Arnon P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kersting, SabinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Labrador, JorgeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lad, DeepeshUNSPECIFIEDorcid.org/0000-0003-3754-7774UNSPECIFIED
Laurenti, LucaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Levin, Mark-DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lista, EnricoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lopez-Garcia, AlbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Malerba, LaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marasca, RobertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marchetti, MoniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marquet, JuanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mattsson, MattiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mauro, Francesca R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Milosevic, IvanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Miras, FatimaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morawska, MartaUNSPECIFIEDorcid.org/0000-0001-6836-2903UNSPECIFIED
Motta, MarinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Munir, TalhaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Murru, RobertaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Niemann, Carsten U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodrigues, Raquel NunesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Olivieri, JacopoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Orsucci, LorellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Papaioannou, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arturo Pavlovsky, MiguelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Piskunova, IngaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Popov, Viola MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Quaglia, Francesca MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Quaresmini, GiuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Qvist, KristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reda, GianluigiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rigolin, Gian MatteoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruchlemer, RosaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saghumyan, GevorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shrestha, AmitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Simkovic, MartinUNSPECIFIEDorcid.org/0000-0003-0331-5334UNSPECIFIED
Spacek, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sportoletti, PaoloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stanca, OanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stavroyianni, NikiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tadmor, TamarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Te Raa, DoreenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tonino, Sanne H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trentin, LivioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Van der Spek, EllenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Gelder, MichelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Kampen, RoelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Varettoni, MarziaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Visentin, AndreaUNSPECIFIEDorcid.org/0000-0003-0271-7200UNSPECIFIED
Vitale, CandidaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wasik-Szczepanek, EwaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wrobel, TomaszUNSPECIFIEDorcid.org/0000-0002-6612-3535UNSPECIFIED
Yanez San Segundo, LucreciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yassin, MohamedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Coscia, MartaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rambaldi, AlessandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Montserrat, EmiliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Foa, RobinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cuneo, AntonioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stamatopoulos, KostasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ghia, PaoloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-608381
DOI: 10.1038/s41375-021-01450-8
Journal or Publication Title: Leukemia
Volume: 35
Number: 12
Page Range: S. 3444 - 3455
Date: 2021
Publisher: SPRINGERNATURE
Place of Publication: LONDON
ISSN: 1476-5551
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Oncology; HematologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60838

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