Universität zu Köln

Freudenmacher, Lars ORCID: 0000-0002-2218-6243, Schauer, Maria, Walkowiak, Wolfgang and von Twickel, Arndt (2020). Refinement of the dopaminergic system of anuran amphibians based on connectivity with habenula, basal ganglia, limbic system, pallium, and spinal cord. J. Comp. Neurol., 528 (6). S. 972 - 989. HOBOKEN: WILEY. ISSN 1096-9861

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Abstract

Whereas our understanding of the dopaminergic system in mammals allows for a distinction between ventral tegmental area (VTA) and substantia nigra pars compacta (SNc), no clear evidence for separate structures in anamniotes has been presented to date. To broaden the insight into the organization and regulation of neuromodulatory systems in anuran amphibians, tracing and immunohistochemical investigations were performed in the Oriental fire-bellied toad, Bombina orientalis. Topographically organized catecholaminergic nigrostriatal, mesolimbic, mesocortical, and spinal cord projections arising from the posterior tubercle and mesencephalic tegmentum were identified. We compared these results with published data from lampreys, chondrichthyes, teleosts, amphibians, reptiles, birds, and mammals. Based on the pattern of organization, as well as the differential innervation by the habenular nuclei, domains gradually comparable to the mammalian paranigral VTA, ventral tier of the SNc, interfascicular nucleus of the VTA, and supramamillary/retromamillary area were identified. Additionally, we could demonstrate topographic separate populations of habenula neurons projecting via a direct excitatory or indirect GABAergic pathway onto the catecholaminergic VTA/SNc homologs and serotonergic raphe nuclei. The indirect GABAergic habenula pathway derives from neurons in the superficial mamillary area, which in terms of its connectivity and chemoarchitecture resembles the mammalian rostromedial tegmental nucleus. These results demonstrate a much more elaborate interconnection principle of the anuran dopaminergic system than previously assumed. Based on the data presented it seems that most features of the dopaminergic system of amniotes had already evolved when the amphibian line of evolution diverged from that leading up to mammals, reptiles, and birds.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Freudenmacher, Lars UNSPECIFIED orcid.org/0000-0002-2218-6243 UNSPECIFIED Schauer, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Walkowiak, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED von Twickel, Arndt UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-127793
DOI:	10.1002/cne.24793
Journal or Publication Title:	J. Comp. Neurol.
Volume:	528
Number:	6
Page Range:	S. 972 - 989
Date:	2020
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1096-9861
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VENTRAL TEGMENTAL AREA; CENTRAL-NERVOUS-SYSTEM; LATERAL HABENULA; TYROSINE-HYDROXYLASE; EFFERENT CONNECTIONS; XENOPUS-LAEVIS; NUCLEUS-ACCUMBENS; SUBSTANTIA-NIGRA; CATECHOLAMINERGIC INNERVATION; INTERPEDUNCULAR CONNECTIONS Multiple languages Neurosciences; Zoology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12779