Universität zu Köln

Lalioti, Maria-Eleni, Kaplani, Konstantina, Lokka, Georgia, Georgomanolis, Theodore, Kyrousi, Christina ORCID: 0000-0002-6234-8382, Dong, Weilai ORCID: 0000-0002-8376-1758, Dunbar, Ashley, Parlapani, Evangelia, Dannianidou, Eleni, Spassky, Nathalie, Kahle, Kristopher T., Papantonis, Argyris, Lygerou, Zoi and Taraviras, Stavros ORCID: 0000-0002-7455-647X (2019). GemC1 is a critical switch for neural stem cell generation in the postnatal brain. Glia, 67 (12). S. 2360 - 2374. HOBOKEN: WILEY. ISSN 1098-1136

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Abstract

The subventricular zone (SVZ) is one of two main niches where neurogenesis persists during adulthood, as it retains neural stem cells (NSCs) with self-renewal capacity and multi-lineage potency. Another critical cellular component of the niche is the population of postmitotic multiciliated ependymal cells. Both cell types are derived from radial glial cells that become specified to each lineage during embryogenesis. We show here that GemC1, encoding Geminin coiled-coil domain-containing protein 1, is associated with congenital hydrocephalus in humans and mice. Our results show that GemC1 deficiency drives cells toward a NSC phenotype, at the expense of multiciliated ependymal cell generation. The increased number of NSCs is accompanied by increased levels of proliferation and neurogenesis in the postnatal SVZ. Finally, GemC1-knockout cells display altered chromatin organization at multiple loci, further supporting a NSC identity. Together, these findings suggest that GemC1 regulates the balance between NSC generation and ependymal cell differentiation, with implications for the pathogenesis of human congenital hydrocephalus.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lalioti, Maria-Eleni UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaplani, Konstantina UNSPECIFIED UNSPECIFIED UNSPECIFIED Lokka, Georgia UNSPECIFIED UNSPECIFIED UNSPECIFIED Georgomanolis, Theodore UNSPECIFIED UNSPECIFIED UNSPECIFIED Kyrousi, Christina UNSPECIFIED orcid.org/0000-0002-6234-8382 UNSPECIFIED Dong, Weilai UNSPECIFIED orcid.org/0000-0002-8376-1758 UNSPECIFIED Dunbar, Ashley UNSPECIFIED UNSPECIFIED UNSPECIFIED Parlapani, Evangelia UNSPECIFIED UNSPECIFIED UNSPECIFIED Dannianidou, Eleni UNSPECIFIED UNSPECIFIED UNSPECIFIED Spassky, Nathalie UNSPECIFIED UNSPECIFIED UNSPECIFIED Kahle, Kristopher T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Papantonis, Argyris UNSPECIFIED UNSPECIFIED UNSPECIFIED Lygerou, Zoi UNSPECIFIED UNSPECIFIED UNSPECIFIED Taraviras, Stavros UNSPECIFIED orcid.org/0000-0002-7455-647X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-134829
DOI:	10.1002/glia.23690
Journal or Publication Title:	Glia
Volume:	67
Number:	12
Page Range:	S. 2360 - 2374
Date:	2019
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1098-1136
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EPENDYMAL CELLS; SUBVENTRICULAR ZONE; EMBRYONIC ORIGIN; DNA-REPLICATION; RADIAL GLIA; GEMININ; TRANSCRIPTOMICS; REGULATOR; FRAMEWORK; MULTICILIOGENESIS Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13482