Universität zu Köln

Thanarajah, Sharmili Edwin, Iglesias, Sandra, Kuzmanovic, Bojana, Rigoux, Lionel, Stephan, Klaas E., Bruening, Jens C. and Tittgemeyer, Marc (2019). Modulation of midbrain neurocircuitry by intranasal insulin. Neuroimage, 194. S. 120 - 128. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1095-9572

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Abstract

Insulin modulates dopamine neuron activity in midbrain and affects processes underlying food intake behaviour, including impulsivity and reward processing. Here, we used intranasal administration and task-free functional MRI in humans to assess time-and dose-dependent effects of insulin on functional connectivity of the dopaminergic midbrain - and how these effects varied depending on systemic insulin sensitivity as measured by HOMA-IR. Specifically, we used a repeated-measures design with factors dose (placebo, 40 IU, 100 IU, 160 IU), time (7 time points during a 90 min post-intervention interval), and group (low vs. high HOMA-IR). A factorial analysis identified a three-way interaction (with whole-brain significance) with regard to functional connectivity between midbrain and the ventromedial prefrontal cortex. This interaction demonstrates that systemic insulin sensitivity modulates the temporal course and dose-dependent effects of intranasal insulin on midbrain functional connectivity. It suggests that altered insulin sensitivity may impact on dopaminergic projections of the midbrain and might underlie the dysregulation of reward-related and motivational behaviour in obesity and diabetes. Perhaps most importantly, the time courses of midbrain functional connectivity we present may provide useful guidance for the design of future human studies that utilize intranasal insulin administration.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Thanarajah, Sharmili Edwin UNSPECIFIED UNSPECIFIED UNSPECIFIED Iglesias, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuzmanovic, Bojana UNSPECIFIED UNSPECIFIED UNSPECIFIED Rigoux, Lionel UNSPECIFIED UNSPECIFIED UNSPECIFIED Stephan, Klaas E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruening, Jens C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tittgemeyer, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-137215
DOI:	10.1016/j.neuroimage.2019.03.050
Journal or Publication Title:	Neuroimage
Volume:	194
Page Range:	S. 120 - 128
Date:	2019
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1095-9572
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VENTRAL TEGMENTAL AREA; FOOD REWARD; SELECTIVE INSULIN; DOPAMINE NEURONS; DECISION-MAKING; HUMAN BRAIN; RESISTANCE; LEPTIN; VALUATION; OBESITY Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13721