Barbe, Anna Greta, Ludwar, Lena, Scharfenberg, Isabel, Hellmich, Martin, Dano, Richard, Barbe, Michael Thomas and Noack, Michael Johannes (2019). Circadian rhythms and influencing factors of xerostomia among Parkinson's disease patients. Oral Dis., 25 (1). S. 282 - 290. HOBOKEN: WILEY. ISSN 1601-0825

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Abstract

Objectives Parkinson's disease (PD) patients suffer from xerostomia, but limited information exists regarding associations with dysphagia, drooling, daily habits, PD characteristics, or possible circadian rhythms. Subjects and methods A questionnaire was administered, including (a) clinical characteristics (comorbidities, prescribed medications, levodopa equivalent daily dose [LEDD], disease duration); (b) self-assessment of dysphagia, xerostomia, drooling (10-cm visual analogue scale [VAS]); (c) 24-hr diary of motor impairment, dyskinesia, xerostomia, dysphagia, drooling, daily habits. Results Of 75 PD patients who completed the study, 67% reported dysphagia (mean +/- standard deviation VAS 4 +/- 2), 76% drooling (5 +/- 2), 77% xerostomia (5 +/- 2). Xerostomia was associated with comorbidities (p = 0.021) and smoking (p = 0.010) and affected by tremor (p = 0.003), dyskinesia (p = 0.010), dysphagia (p < 0.001), food intake (p = 0.005), sleep (p = 0.011), age (p = 0.018), medication intake (p = 0.063), LEDD (p = 0.052), daytime (p = 0.075), disease duration (p = 0.004). Xerostomia peaked at 9 a.m. and 9 p.m. Conclusions PD patients suffer from xerostomia, dysphagia, and drooling. Subjective dysphagia is associated with drooling and xerostomia, but drooling prevalence or intensity does not influence xerostomia symptoms. Tremor, dyskinesia, and disease duration, which characterise PD, affect xerostomia. Additionally, food intake, sleep, age, LEDD, and daytime (peaks at 9 a.m. and 9 p.m.) increase xerostomia occurrence. This knowledge may improve dentists' advice to patients and aid development of patient-centred, symptom-relieving products.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Barbe, Anna GretaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ludwar, LenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scharfenberg, IsabelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hellmich, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dano, RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barbe, Michael ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Noack, Michael JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-140980
DOI: 10.1111/odi.12942
Journal or Publication Title: Oral Dis.
Volume: 25
Number: 1
Page Range: S. 282 - 290
Date: 2019
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1601-0825
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
QUALITY-OF-LIFE; L-DOPA; DYSPHAGIA; RADIOTHERAPY; DYSFUNCTION; SYMPTOMS; IMPACT; SAMPLEMultiple languages
Dentistry, Oral Surgery & MedicineMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/14098

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