Universität zu Köln

Liebenthron, Jana, Montag, Markus, Reinsberg, Jochen, Koester, Maria, Isachenko, Vladimir, van der Ven, Katrin, van der Ven, Hans, Kruessel, Jan-Steffen and von Wolff, Michael ORCID: 0000-0003-4303-2734 (2019). Overnight ovarian tissue transportation for centralized cryobanking: a feasible option. Reprod. Biomed. Online, 38 (5). S. 740 - 750. OXFORD: ELSEVIER SCI LTD. ISSN 1472-6491

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Abstract

Research question: Is overnight transportation of ovarian tissue before cryopreservation in a centralized cryobank from the FertiPROTEKT network feasible? Design: Data from 1810 women with cryopreserved ovarian tissue after overnight transportation from December 2000 to December 2017 were analysed with a focus on transportation, tissue activity parameters and pregnancy, and delivery rates after transplantation. Results: A total of 92.4% of tissue samples arrived at ideal temperatures of 2-8 degrees C, 0.4% were transported at temperatures lower than ideal and 6.4% were transported at temperatures that were too high, generally due to mishandling of the inlayed cool packs of the transportation boxes. In 62 women, 78 tissue transplantations were carried out. A subgroup of 30 women who underwent a single orthotopic transplantation with fulfilled criteria of a complete follow-up after transplantation until the end of study, a premature ovarian insufficiency after gonadotoxic therapy as well as the absence of pelvic radiation, was further analysed. In this group, transplantations into a peritoneal pocket accounted for 90%. Transplants were still active at 1 year and above after transplantation in 93.3%. Pregnancy and delivery rates were 46.7% and 43.3%, respectively, with one ongoing pregnancy at the end of the study. Conclusions: Overnight transportation for central cryobanking is a feasible concept that results in high reproducible success rates through standardized professional tissue freezing and storage.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Liebenthron, Jana UNSPECIFIED UNSPECIFIED UNSPECIFIED Montag, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Reinsberg, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Koester, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Isachenko, Vladimir UNSPECIFIED UNSPECIFIED UNSPECIFIED van der Ven, Katrin UNSPECIFIED UNSPECIFIED UNSPECIFIED van der Ven, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Kruessel, Jan-Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED von Wolff, Michael UNSPECIFIED orcid.org/0000-0003-4303-2734 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-150131
DOI:	10.1016/j.rbmo.2019.01.006
Journal or Publication Title:	Reprod. Biomed. Online
Volume:	38
Number:	5
Page Range:	S. 740 - 750
Date:	2019
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1472-6491
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FERTILITY-PRESERVATION; IN-VITRO; CORTEX TRANSPLANTATION; PRIMORDIAL FOLLICLES; MALIGNANT-CELLS; LIVE BIRTHS; CRYOPRESERVATION; WOMEN; EFFICACY; NETWORK Multiple languages Obstetrics & Gynecology; Reproductive Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15013