Jessen, Frank (2019). Early detection of Alzheimer's disease and approaches for prevention. Bundesgesundheitsblatt-Gesund., 62 (3). S. 255 - 261. NEW YORK: SPRINGER. ISSN 1437-1588

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Abstract

Due to the aging population, within the next 20-30years the number of individuals with dementia, mostly due to Alzheimer's disease (AD), will drastically increase. Since acure for the disease will not be available in the near future, early disease detection and prevention are of central importance for slowing symptom progression and maintaining independency and quality of life.In this narrative review, the current state of research in early disease detection and prediction of AD as well as lifestyle-based and molecular prevention approaches are presented.With biomarkers for the core pathology of AD, it is possible to predict the risk for dementia in individuals within the prodromal phase of the disease, which extends up to 10years. It is estimated that up to 30% of the risk of dementia is attributable to modifiable factors. Accordingly, some multimodal lifestyle-based interventions show protective effects on cognition in at-risk subjects. Anti-amyloid treatment is currently being studied in patients with mild cognitive impairment and in individuals without symptoms, but with high genetic risk for AD.Early diagnosis, prediction, and prevention of AD are the main challenges to overcome the potentially drastic increases in individuals with dementia within the next decades. These challenges are associated with complex medical, ethical, legal, and economic questions.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-155285
DOI: 10.1007/s00103-019-02877-2
Journal or Publication Title: Bundesgesundheitsblatt-Gesund.
Volume: 62
Number: 3
Page Range: S. 255 - 261
Date: 2019
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1437-1588
Language: German
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MILD COGNITIVE IMPAIRMENT; PREVALENCE; DEMENTIA; DECLINE; ASSOCIATION; PROGRESSION; BIOMARKERS; ADULTS; RISKMultiple languages
Public, Environmental & Occupational HealthMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/15528

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