Thomassen, Jan C., Mueller, Matthias I., Alcazar, Miguel A. Alejandre, Rietschel, Ernst and van Koningsbruggen-Rietschel, Silke (2018). Effect of Lumacaftor/Ivacaftor on glucose metabolism and insulin secretion in Phe508del homozygous cystic fibrosis patients. J. Cyst. Fibros, 17 (2). S. 271 - 276. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1873-5010
Full text not available from this repository.Abstract
Objective: To investigate the effect of Lumacaftor/Ivacaftor on glucose metabolism and insulin secretion in patients with cystic fibrosis (CF) (Phe508del/Phe508de1). Methods: A standard oral glucose tolerance test (OGTT) and an intravenous glucose tolerance test (IVGTT) were performed to investigate glucose metabolism and insulin secretion before and after 6-8 weeks of treatment with Lumacaftor/Ivacaftor in 5 Phe508del-homozygous CF patients. The area under the curve (AUC) for glucose and insulin levels was calculated using the trapezoidal approximation. Results: 5 participants were investigated. Treatment with Lumacaftor/Ivacaftor was followed by an improvement of the 2 h glucose levels in 3 patients and worsening in 2 patients. Analysis of the time course of blood glucose levels during OGTT revealed an increase of the AUC in 3 of 5 patients. In response to IVGTT, acute insulin secretion improved in 2 patients and worsened in 3. Conclusion: The investigation could not demonstrate that treatment with Lumacaftor/Ivacaftor had a consistent impact on glucose tolerance and insulin secretion. Further adequately-powered studies examining glucose metabolism are needed to properly evaluate drug response in the endocrine pancreas and to test whether this treatment could eventually prevent the development of cystic fibrosis-related diabetes (CFRD). (C) 2017 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
Item Type: | Journal Article | ||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-193960 | ||||||||||||||||||||||||
DOI: | 10.1016/j.jcf.2017.11.016 | ||||||||||||||||||||||||
Journal or Publication Title: | J. Cyst. Fibros | ||||||||||||||||||||||||
Volume: | 17 | ||||||||||||||||||||||||
Number: | 2 | ||||||||||||||||||||||||
Page Range: | S. 271 - 276 | ||||||||||||||||||||||||
Date: | 2018 | ||||||||||||||||||||||||
Publisher: | ELSEVIER SCIENCE BV | ||||||||||||||||||||||||
Place of Publication: | AMSTERDAM | ||||||||||||||||||||||||
ISSN: | 1873-5010 | ||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||
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Refereed: | Yes | ||||||||||||||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/19396 |
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