Universität zu Köln

Beck, Anne-Kathrin, Luetjens, Goetz, Schwabe, Kerstin, Dengler, Reinhard, Krauss, Joachim K. and Sandmann, Pascale (2018). Thalamic and basal ganglia regions are involved in attentional processing of behaviorally significant events: evidence from simultaneous depth and scalp EEG. Brain Struct. Funct., 223 (1). S. 461 - 475. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1863-2661

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Abstract

Extensive descriptions exist on cortical responses to change in the acoustic environment. However, the involvement of subcortical regions is not well understood. Here we present simultaneous recordings of cortical and subcortical event-related potentials (ERPs) to different pure tones in patients undergoing surgery for deep brain stimulation (DBS). These patients had externalized electrodes in the subthalamic nucleus (STN), the ventrolateral posterior thalamus (VLp) or the globus pallidus internus (GPi). Subcortical and cortical ERPs were analyzed upon presentation of one frequent non-target stimulus and two infrequent stimuli, either being a target or a distractor stimulus. The results revealed that amplitudes of scalp-recorded P3 and subcortical late attention-modulated responses (AMR) were largest upon presentation of target stimuli compared with distractor stimuli. This suggests that thalamic and basal ganglia regions are sensitive to behaviorally relevant auditory events. Comparison of the subcortical structures showed that responses in VLp have shorter latency than in GPi and STN. Further, the subcortical responses in VLp and STN emerged significantly prior to the cortical P3 response. Our findings point to higher-order cognitive functions already at a subcortical level. Auditory events are categorized as behaviorally relevant in subcortical loops involving basal ganglia and thalamic regions. This label is then distributed to cortical regions by ascending projections.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Beck, Anne-Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Luetjens, Goetz UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwabe, Kerstin UNSPECIFIED UNSPECIFIED UNSPECIFIED Dengler, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Krauss, Joachim K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sandmann, Pascale UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-204502
DOI:	10.1007/s00429-017-1506-z
Journal or Publication Title:	Brain Struct. Funct.
Volume:	223
Number:	1
Page Range:	S. 461 - 475
Date:	2018
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1863-2661
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INDEPENDENT COMPONENT ANALYSIS; SUBTHALAMIC NUCLEUS; COCHLEAR IMPLANTATION; MENTAL CHRONOMETRY; NEURAL GENERATORS; AUDITORY-STIMULI; P300; AROUSAL; LATENCY; POTENTIALS Multiple languages Anatomy & Morphology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20450