Universität zu Köln

Chretien, Anne-Sophie, Fauriat, Cyril ORCID: 0000-0002-4850-6831, Orlanducci, Florence, Rey, Jerome, Borg, Gaelle Bouvier, Gautherot, Emmanuel, Granjeaud, Samuel ORCID: 0000-0001-9245-1535, Demerle, Clemence, Hamel, Jean-Francois, Cerwenka, Adelheid, von Strandmann, Elke Pogge, Ifrah, Norbert, Lacombe, Catherine, Cornillet-Lefebvre, Pascale, Delaunay, Jacques, Toubert, Antoine ORCID: 0000-0002-7308-7317, Arnoulet, Christine, Vey, Norbert and Olive, Daniel (2017). NKp30 expression is a prognostic immune biomarker for stratification of patients with intermediate-risk acute myeloid leukemia. Oncotarget, 8 (30). S. 49548 - 49564. ORCHARD PARK: IMPACT JOURNALS LLC. ISSN 1949-2553

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Abstract

Cytogenetics and European Leukemia Net (ELN) genetic classification predict patients at increased risk of relapse in acute myeloid leukemia (AML) except in the intermediate risk group for which further prognostic determinants are required. We have previously shown that Natural Killer (NK) cell defects in AML are predictors of poor overall survival (OS). This study aimins at validating NKp30, a receptor that mediates NK activation, as a prognostic biomarker for AML patients with intermediate prognosis. NKp30 expression was prospectively assessed at diagnosis on NK cells from peripheral blood by flow cytometry (N = 201 patients). Clinical outcome was evaluated with regard to NKp30 status. In patients with intermediate cytogenetic (N = 162), NKp30(high) phenotype at diagnosis was predictive of better OS (HR = 0.26; 95% CI = [0.14-0.50]; P < 0.0001) and relapse-free survival (RFS) (HR = 0.21; 95% CI = [0.08-0.52]; P = 0.0007). In patients with intermediate ELN (N = 116), NKp30(high) phenotype at diagnosis was predictive of better OS (HR = 0.33; 95% CI = [0.16-0.67]; P = 0.0019) and RFS (HR = 0.24; 95% CI = [0.08-0.67]; P = 0.0058). In multivariate analysis, high NKp30 expression independently predicted improved OS (HR = 0.56, P = 0.046) and RFS (HR = 0.37, P = 0.048). Consistently, cumulative incidence of relapse (CIR) was lower in patients with high NKp30 expression (HR = 0.37, P = 0.026). In conclusion, we propose NKp30 status as a simple and early prognostic biomarker that identifies intermediate-risk patients with poor prognosis who otherwise may not be identified with existing risk stratification systems.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Chretien, Anne-Sophie UNSPECIFIED UNSPECIFIED UNSPECIFIED Fauriat, Cyril UNSPECIFIED orcid.org/0000-0002-4850-6831 UNSPECIFIED Orlanducci, Florence UNSPECIFIED UNSPECIFIED UNSPECIFIED Rey, Jerome UNSPECIFIED UNSPECIFIED UNSPECIFIED Borg, Gaelle Bouvier UNSPECIFIED UNSPECIFIED UNSPECIFIED Gautherot, Emmanuel UNSPECIFIED UNSPECIFIED UNSPECIFIED Granjeaud, Samuel UNSPECIFIED orcid.org/0000-0001-9245-1535 UNSPECIFIED Demerle, Clemence UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamel, Jean-Francois UNSPECIFIED UNSPECIFIED UNSPECIFIED Cerwenka, Adelheid UNSPECIFIED UNSPECIFIED UNSPECIFIED von Strandmann, Elke Pogge UNSPECIFIED UNSPECIFIED UNSPECIFIED Ifrah, Norbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Lacombe, Catherine UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornillet-Lefebvre, Pascale UNSPECIFIED UNSPECIFIED UNSPECIFIED Delaunay, Jacques UNSPECIFIED UNSPECIFIED UNSPECIFIED Toubert, Antoine UNSPECIFIED orcid.org/0000-0002-7308-7317 UNSPECIFIED Arnoulet, Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Vey, Norbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Olive, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-224736
DOI:	10.18632/oncotarget.17747
Journal or Publication Title:	Oncotarget
Volume:	8
Number:	30
Page Range:	S. 49548 - 49564
Date:	2017
Publisher:	IMPACT JOURNALS LLC
Place of Publication:	ORCHARD PARK
ISSN:	1949-2553
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NATURAL-KILLER-CELLS; LONG-TERM SURVIVAL; NK CELLS; POSTREMISSION THERAPY; AML; DIAGNOSIS; TRANSPLANTATION; RECOMMENDATIONS; CLASSIFICATION; CYTOTOXICITY Multiple languages Oncology; Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22473