Theess, Wiebke, Sellau, Julie ORCID: 0000-0001-9921-4823, Steeg, Christiane, Klinke, Anna, Baldus, Stephan, Cramer, Jakob P. and Jacobs, Thomas (2017). Myeloperoxidase Attenuates Pathogen Clearance during Plasmodium yoelii Nonlethal Infection. Infect. Immun., 85 (1). WASHINGTON: AMER SOC MICROBIOLOGY. ISSN 1098-5522

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Abstract

Myeloperoxidase (MPO), a leukocyte-derived enzyme mainly secreted by activated neutrophils, is known to be involved in the immune response during bacterial and fungal infection and inflammatory diseases. Nevertheless, the role of MPO in a parasitic disease like malaria is unknown. We hypothesized that MPO contributes to parasite clearance. To address this hypothesis, we used Plasmodium yoelii nonlethal infection in wild-type and MPO-deficient mice as a murine malaria model. We detected high MPO plasma levels in wild-type mice with Plasmodium yoelii infection. Unexpectedly, infected MPO-deficient mice did not show increased parasite loads but were able to clear the infection more rapidly than wild-type mice. Additionally, the presence of neutrophils at the onset of infection seemed not to be essential for the control of the parasitemia. The effect of decreased parasite levels in MPO-deficient mice was absent from animals lacking mature T and B cells, indicating that this effect is most likely dependent on adaptive immune response mechanisms. Indeed, we observed increased gamma interferon and tumor necrosis factor alpha production by T cells in infected MPO-deficient mice. Together, these results suggest that MPO modulates the adaptive immune response during malaria infection, leading to an attenuated parasite clearance.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Theess, WiebkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sellau, JulieUNSPECIFIEDorcid.org/0000-0001-9921-4823UNSPECIFIED
Steeg, ChristianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klinke, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baldus, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cramer, Jakob P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jacobs, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-247013
DOI: 10.1128/IAI.00475-16
Journal or Publication Title: Infect. Immun.
Volume: 85
Number: 1
Date: 2017
Publisher: AMER SOC MICROBIOLOGY
Place of Publication: WASHINGTON
ISSN: 1098-5522
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NEUTROPHIL EXTRACELLULAR TRAPS; FALCIPARUM-MALARIA; IMMUNE-RESPONSES; IN-VITRO; B-CELLS; MICE; BLOOD; STAGE; INFLAMMATION; DEFICIENCYMultiple languages
Immunology; Infectious DiseasesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/24701

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