Universität zu Köln

Brucker, Janina, Mayer, Christine, Gebauer, Gerhard, Mallmann, Peter, Belau, Antje Kristina, Schneeweiss, Andreas, Sohn, Christof and Eichbaum, Michael (2016). Non-pegylated liposomal doxorubicin for patients with recurrent ovarian cancer: A multicentric phase II trial. Oncol. Lett., 12 (2). S. 1211 - 1216. ATHENS: SPANDIDOS PUBL LTD. ISSN 1792-1082

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Abstract

Patients with non-platinum-sensitive recurrent ovarian cancer have a poor prognosis. Non-pegylated liposomal doxorubicin (Myocet (R)) is a promising drug that may be able to improve treatment for such patients. In the current study, patients with recurrent ovarian cancer relapsing within 12 months after primary treatment received non-pegylated liposomal doxorubicin at 75 mg/m(2) d1q22 and 60 mg/m2 d1q22 after study dose modification, respectively. There were 29 patients enrolled in the trial, and 124 cycles of non-pegylated liposomal doxorubicin were administered in total. All 29 patients were evaluable for toxicity. The clinical benefit rate (defined as the proportion of patients with either complete remission or partial remission, or with stable disease for >6 months) was 50%. The predominant non-hematological toxicity was nausea and vomiting (18 patients, grade I/II), whilst no palmar plantar erythrodysesthesia was observed. In 3 patients, a grade III hematological toxicity occurred, and the treatment schedule was consequently modified to 60 mg/m2 d1q22. The findings suggest that non-pegylated liposomal doxorubicin administered in a schedule of 60 mg/m(2) d1q22 is well-manageable and is associated with tolerable non-hematological toxicities (predominantly nausea).

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Brucker, Janina UNSPECIFIED UNSPECIFIED UNSPECIFIED Mayer, Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Gebauer, Gerhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Mallmann, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Belau, Antje Kristina UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneeweiss, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Sohn, Christof UNSPECIFIED UNSPECIFIED UNSPECIFIED Eichbaum, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-268457
DOI:	10.3892/ol.2016.4740
Journal or Publication Title:	Oncol. Lett.
Volume:	12
Number:	2
Page Range:	S. 1211 - 1216
Date:	2016
Publisher:	SPANDIDOS PUBL LTD
Place of Publication:	ATHENS
ISSN:	1792-1082
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PALMAR-PLANTAR ERYTHRODYSESTHESIA; MANAGEMENT STRATEGIES; REFRACTORY OVARIAN; PACLITAXEL Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26845